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ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis

The strongest genetic risk factor for sporadic Alzheimer’s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis. Being astrocytes the main producers of cholesterol and ApoE in the brain, we investigated...

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Detalles Bibliográficos
Autores principales:	Staurenghi, Erica, Leoni, Valerio, Lo Iacono, Marco, Sottero, Barbara, Testa, Gabriella, Giannelli, Serena, Leonarduzzi, Gabriella, Gamba, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686673/ https://www.ncbi.nlm.nih.gov/pubmed/36358540 http://dx.doi.org/10.3390/antiox11112168

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