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Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD

Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the liver is a major feature of NAFLD. Given the lack...

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Autores principales: Martín-Fernández, Marta, Arroyo, Víctor, Carnicero, Carmen, Sigüenza, Rebeca, Busta, Reyes, Mora, Natalia, Antolín, Beatriz, Tamayo, Eduardo, Aspichueta, Patricia, Carnicero-Frutos, Irene, Gonzalo-Benito, Hugo, Aller, Rocío
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686676/
https://www.ncbi.nlm.nih.gov/pubmed/36358589
http://dx.doi.org/10.3390/antiox11112217
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author Martín-Fernández, Marta
Arroyo, Víctor
Carnicero, Carmen
Sigüenza, Rebeca
Busta, Reyes
Mora, Natalia
Antolín, Beatriz
Tamayo, Eduardo
Aspichueta, Patricia
Carnicero-Frutos, Irene
Gonzalo-Benito, Hugo
Aller, Rocío
author_facet Martín-Fernández, Marta
Arroyo, Víctor
Carnicero, Carmen
Sigüenza, Rebeca
Busta, Reyes
Mora, Natalia
Antolín, Beatriz
Tamayo, Eduardo
Aspichueta, Patricia
Carnicero-Frutos, Irene
Gonzalo-Benito, Hugo
Aller, Rocío
author_sort Martín-Fernández, Marta
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the liver is a major feature of NAFLD. Given the lack of a non-invasive and reliable methods for the diagnosis of non-alcoholic steatohepatitis (NASH), it is important to find serum markers that are capable of discriminating or defining patients with this stage of NASH. Blood samples were obtained from 152 Caucasian subjects with biopsy-proven NAFLD due to persistently elevated liver enzyme levels. Metabolites representative of oxidative stress were assessed. The findings derived from this work revealed that NAFLD patients with a NASH score of ≥ 4 showed significantly higher levels of lipid peroxidation (LPO). Indeed, LPO levels above the optimal operating point (OOP) of 315.39 μM are an independent risk factor for presenting a NASH score of ≥ 4 (OR: 4.71; 95% CI: 1.68–13.19; p = 0.003). The area under the curve (AUC = 0.81, 95% CI = 0.73–0.89, p < 0.001) shows a good discrimination ability of the model. Therefore, understanding the molecular mechanisms underlying the basal inflammation present in these patients is postulated as a possible source of biomarkers and therapeutic targets in NASH.
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spelling pubmed-96866762022-11-25 Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD Martín-Fernández, Marta Arroyo, Víctor Carnicero, Carmen Sigüenza, Rebeca Busta, Reyes Mora, Natalia Antolín, Beatriz Tamayo, Eduardo Aspichueta, Patricia Carnicero-Frutos, Irene Gonzalo-Benito, Hugo Aller, Rocío Antioxidants (Basel) Article Non-alcoholic fatty liver disease (NAFLD) is characterised by an excess of hepatic fat that can progress to steatohepatitis, fibrosis, cirrhosis and hepatocarcinoma. The imbalance between lipid uptake/lipogenesis and lipid oxidation/secretion in the liver is a major feature of NAFLD. Given the lack of a non-invasive and reliable methods for the diagnosis of non-alcoholic steatohepatitis (NASH), it is important to find serum markers that are capable of discriminating or defining patients with this stage of NASH. Blood samples were obtained from 152 Caucasian subjects with biopsy-proven NAFLD due to persistently elevated liver enzyme levels. Metabolites representative of oxidative stress were assessed. The findings derived from this work revealed that NAFLD patients with a NASH score of ≥ 4 showed significantly higher levels of lipid peroxidation (LPO). Indeed, LPO levels above the optimal operating point (OOP) of 315.39 μM are an independent risk factor for presenting a NASH score of ≥ 4 (OR: 4.71; 95% CI: 1.68–13.19; p = 0.003). The area under the curve (AUC = 0.81, 95% CI = 0.73–0.89, p < 0.001) shows a good discrimination ability of the model. Therefore, understanding the molecular mechanisms underlying the basal inflammation present in these patients is postulated as a possible source of biomarkers and therapeutic targets in NASH. MDPI 2022-11-10 /pmc/articles/PMC9686676/ /pubmed/36358589 http://dx.doi.org/10.3390/antiox11112217 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martín-Fernández, Marta
Arroyo, Víctor
Carnicero, Carmen
Sigüenza, Rebeca
Busta, Reyes
Mora, Natalia
Antolín, Beatriz
Tamayo, Eduardo
Aspichueta, Patricia
Carnicero-Frutos, Irene
Gonzalo-Benito, Hugo
Aller, Rocío
Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_full Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_fullStr Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_full_unstemmed Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_short Role of Oxidative Stress and Lipid Peroxidation in the Pathophysiology of NAFLD
title_sort role of oxidative stress and lipid peroxidation in the pathophysiology of nafld
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686676/
https://www.ncbi.nlm.nih.gov/pubmed/36358589
http://dx.doi.org/10.3390/antiox11112217
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