Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant Pseudomonas aeruginosa: In Vivo and In Vitro Evidence

This study correlates in vivo findings in a patient with an extensively drug-resistant (XDR) P. aeruginosa infection who developed resistance to ceftazidime-avibactam (CAZ-AVI) with in vitro results of a 7-day hollow-fiber infection model (HFIM) testing the same bacterial strain. The patient was cri...

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Detalles Bibliográficos
Autores principales: Lopez-Montesinos, Inmaculada, Montero, María Milagro, Domene-Ochoa, Sandra, López-Causapé, Carla, Echeverria, Daniel, Sorlí, Luisa, Campillo, Nuria, Luque, Sonia, Padilla, Eduardo, Prim, Nuria, Grau, Santiago, Oliver, Antonio, Horcajada, Juan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686790/
https://www.ncbi.nlm.nih.gov/pubmed/36358110
http://dx.doi.org/10.3390/antibiotics11111456

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