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Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats
This study examined the effects of exposure to lead acetate (PbAc) and/or aluminum trioxide nanoparticles (Al(2)O(3)NPs) on testicular function. Additionally, the probable reproprotective effects of quercetin (QTN) against Al(2)O(3)NPs and PbAc co-exposure in male Sprague Dawely rats were assessed....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686927/ https://www.ncbi.nlm.nih.gov/pubmed/36358505 http://dx.doi.org/10.3390/antiox11112133 |
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author | Behairy, Amany Hashem, Mohamed M. Abo-El-Sooud, Khaled El-Metwally, Abeer E. Hassan, Bayan A. Abd-Elhakim, Yasmina M. |
author_facet | Behairy, Amany Hashem, Mohamed M. Abo-El-Sooud, Khaled El-Metwally, Abeer E. Hassan, Bayan A. Abd-Elhakim, Yasmina M. |
author_sort | Behairy, Amany |
collection | PubMed |
description | This study examined the effects of exposure to lead acetate (PbAc) and/or aluminum trioxide nanoparticles (Al(2)O(3)NPs) on testicular function. Additionally, the probable reproprotective effects of quercetin (QTN) against Al(2)O(3)NPs and PbAc co-exposure in male Sprague Dawely rats were assessed. Al(2)O(3)NPs (100 mg/kg b.wt.), PbAc (50 mg/kg b.wt.), and QTN (20 mg/kg b.wt.) were orally administered for 60 days. Then, spermiogram, histopathological examinations of the testis and accessory glands, and immunohistochemical detection of androgen receptors (AR) and tumor necrotic factor alpha (TNF-α) were achieved. Moreover, serum levels of male sex hormones and testicular levels of antioxidant indices were estimated. The results showed that Al(2)O(3)NP(s) and/or PbAc caused significant sperm abnormalities, testicular oxidative stress, and histopathological changes. Furthermore, serum testosterone, LH, and FSH levels significantly decreased, while estradiol levels significantly increased. The Al(2)O(3)NPs and/or PbAc co-exposed group had more obvious disturbances. Furthermore, QTN co-administration significantly reversed the Al(2)O(3)NPs and PbAc-induced testicular histopathological alterations, reduced antioxidant defenses, and altered AR and TNF-α immune expression in testicular tissues. Conclusively, Al(2)O(3)NPs and/or PbAc evoked testicular dysfunction by inducing oxidative injury and inflammation. However, QTN oral dosing effectively mitigated the negative effects of Al(2)O(3)NPs and PbAc by suppressing oxidative stress and inflammation and improving the antioxidant defense system. |
format | Online Article Text |
id | pubmed-9686927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96869272022-11-25 Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats Behairy, Amany Hashem, Mohamed M. Abo-El-Sooud, Khaled El-Metwally, Abeer E. Hassan, Bayan A. Abd-Elhakim, Yasmina M. Antioxidants (Basel) Article This study examined the effects of exposure to lead acetate (PbAc) and/or aluminum trioxide nanoparticles (Al(2)O(3)NPs) on testicular function. Additionally, the probable reproprotective effects of quercetin (QTN) against Al(2)O(3)NPs and PbAc co-exposure in male Sprague Dawely rats were assessed. Al(2)O(3)NPs (100 mg/kg b.wt.), PbAc (50 mg/kg b.wt.), and QTN (20 mg/kg b.wt.) were orally administered for 60 days. Then, spermiogram, histopathological examinations of the testis and accessory glands, and immunohistochemical detection of androgen receptors (AR) and tumor necrotic factor alpha (TNF-α) were achieved. Moreover, serum levels of male sex hormones and testicular levels of antioxidant indices were estimated. The results showed that Al(2)O(3)NP(s) and/or PbAc caused significant sperm abnormalities, testicular oxidative stress, and histopathological changes. Furthermore, serum testosterone, LH, and FSH levels significantly decreased, while estradiol levels significantly increased. The Al(2)O(3)NPs and/or PbAc co-exposed group had more obvious disturbances. Furthermore, QTN co-administration significantly reversed the Al(2)O(3)NPs and PbAc-induced testicular histopathological alterations, reduced antioxidant defenses, and altered AR and TNF-α immune expression in testicular tissues. Conclusively, Al(2)O(3)NPs and/or PbAc evoked testicular dysfunction by inducing oxidative injury and inflammation. However, QTN oral dosing effectively mitigated the negative effects of Al(2)O(3)NPs and PbAc by suppressing oxidative stress and inflammation and improving the antioxidant defense system. MDPI 2022-10-28 /pmc/articles/PMC9686927/ /pubmed/36358505 http://dx.doi.org/10.3390/antiox11112133 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Behairy, Amany Hashem, Mohamed M. Abo-El-Sooud, Khaled El-Metwally, Abeer E. Hassan, Bayan A. Abd-Elhakim, Yasmina M. Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats |
title | Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats |
title_full | Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats |
title_fullStr | Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats |
title_full_unstemmed | Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats |
title_short | Quercetin Abates Aluminum Trioxide Nanoparticles and Lead Acetate Induced Altered Sperm Quality, Testicular Oxidative Damage, and Sexual Hormones Disruption in Male Rats |
title_sort | quercetin abates aluminum trioxide nanoparticles and lead acetate induced altered sperm quality, testicular oxidative damage, and sexual hormones disruption in male rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686927/ https://www.ncbi.nlm.nih.gov/pubmed/36358505 http://dx.doi.org/10.3390/antiox11112133 |
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