Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation

A scarcity of functionally validated enhancers in the human genome presents a significant hurdle to understanding how these cis-regulatory elements contribute to human diseases. We carry out highly multiplexed CRISPR-based perturbation and sequencing to identify enhancers required for cell prolifera...

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Detalles Bibliográficos
Autores principales: Chen, Poshen B., Fiaux, Patrick C., Zhang, Kai, Li, Bin, Kubo, Naoki, Jiang, Shan, Hu, Rong, Rooholfada, Emma, Wu, Sihan, Wang, Mengchi, Wang, Wei, McVicker, Graham, Mischel, Paul S., Ren, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687083/
https://www.ncbi.nlm.nih.gov/pubmed/36351387
http://dx.doi.org/10.1016/j.celrep.2022.111630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687083/
https://www.ncbi.nlm.nih.gov/pubmed/36351387
http://dx.doi.org/10.1016/j.celrep.2022.111630

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