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Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers
Objectives: The intranasal route represents a high promising route of administration aiming for brain delivery. Yet, it represents one of the most difficult and complicated routes. Accordingly, scientists are in a continuous search for novel drug delivery vehicles such as the lipid and polymeric nan...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687115/ https://www.ncbi.nlm.nih.gov/pubmed/36354558 http://dx.doi.org/10.3390/bioengineering9110647 |
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author | Hathout, Rania M. El-Marakby, Eman M. |
author_facet | Hathout, Rania M. El-Marakby, Eman M. |
author_sort | Hathout, Rania M. |
collection | PubMed |
description | Objectives: The intranasal route represents a high promising route of administration aiming for brain delivery. Yet, it represents one of the most difficult and complicated routes. Accordingly, scientists are in a continuous search for novel drug delivery vehicles such as the lipid and polymeric nanoparticles that are apt to enhance the bioavailability of the administered drugs to reach the brain. In this study, a certain number of publications were selected from different databases and literature. Meta-analysis studies using two different algorithms (DerSimonian–Laird and inverse variance) followed aiming to explore the published studies and confirm by evidence the superiority of nanocarriers in enhancing the brain bioavailability of various drugs. Furthermore, the quantitative comparison of lipid versus polymeric nanosystems was performed. Methods: The area under the curve (AUC) as an important pharmacokinetic parameter extracted from in vivo animal studies was designated as the “effect” in the performed meta-analysis after normalization. Forest plots were generated. Key findings and Conclusions: The meta-analysis confirmed the augmentation of the AUC after the comparison with traditional preparations such as solutions and suspensions. Most importantly, lipid nanoparticles were proven to be significantly superior to the polymeric counterparts. |
format | Online Article Text |
id | pubmed-9687115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96871152022-11-25 Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers Hathout, Rania M. El-Marakby, Eman M. Bioengineering (Basel) Article Objectives: The intranasal route represents a high promising route of administration aiming for brain delivery. Yet, it represents one of the most difficult and complicated routes. Accordingly, scientists are in a continuous search for novel drug delivery vehicles such as the lipid and polymeric nanoparticles that are apt to enhance the bioavailability of the administered drugs to reach the brain. In this study, a certain number of publications were selected from different databases and literature. Meta-analysis studies using two different algorithms (DerSimonian–Laird and inverse variance) followed aiming to explore the published studies and confirm by evidence the superiority of nanocarriers in enhancing the brain bioavailability of various drugs. Furthermore, the quantitative comparison of lipid versus polymeric nanosystems was performed. Methods: The area under the curve (AUC) as an important pharmacokinetic parameter extracted from in vivo animal studies was designated as the “effect” in the performed meta-analysis after normalization. Forest plots were generated. Key findings and Conclusions: The meta-analysis confirmed the augmentation of the AUC after the comparison with traditional preparations such as solutions and suspensions. Most importantly, lipid nanoparticles were proven to be significantly superior to the polymeric counterparts. MDPI 2022-11-03 /pmc/articles/PMC9687115/ /pubmed/36354558 http://dx.doi.org/10.3390/bioengineering9110647 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hathout, Rania M. El-Marakby, Eman M. Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers |
title | Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers |
title_full | Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers |
title_fullStr | Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers |
title_full_unstemmed | Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers |
title_short | Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers |
title_sort | meta-analysis: a convenient tool for the choice of nose-to-brain nanocarriers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687115/ https://www.ncbi.nlm.nih.gov/pubmed/36354558 http://dx.doi.org/10.3390/bioengineering9110647 |
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