Cargando…

Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers

Objectives: The intranasal route represents a high promising route of administration aiming for brain delivery. Yet, it represents one of the most difficult and complicated routes. Accordingly, scientists are in a continuous search for novel drug delivery vehicles such as the lipid and polymeric nan...

Descripción completa

Detalles Bibliográficos
Autores principales: Hathout, Rania M., El-Marakby, Eman M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687115/
https://www.ncbi.nlm.nih.gov/pubmed/36354558
http://dx.doi.org/10.3390/bioengineering9110647
_version_ 1784835923254444032
author Hathout, Rania M.
El-Marakby, Eman M.
author_facet Hathout, Rania M.
El-Marakby, Eman M.
author_sort Hathout, Rania M.
collection PubMed
description Objectives: The intranasal route represents a high promising route of administration aiming for brain delivery. Yet, it represents one of the most difficult and complicated routes. Accordingly, scientists are in a continuous search for novel drug delivery vehicles such as the lipid and polymeric nanoparticles that are apt to enhance the bioavailability of the administered drugs to reach the brain. In this study, a certain number of publications were selected from different databases and literature. Meta-analysis studies using two different algorithms (DerSimonian–Laird and inverse variance) followed aiming to explore the published studies and confirm by evidence the superiority of nanocarriers in enhancing the brain bioavailability of various drugs. Furthermore, the quantitative comparison of lipid versus polymeric nanosystems was performed. Methods: The area under the curve (AUC) as an important pharmacokinetic parameter extracted from in vivo animal studies was designated as the “effect” in the performed meta-analysis after normalization. Forest plots were generated. Key findings and Conclusions: The meta-analysis confirmed the augmentation of the AUC after the comparison with traditional preparations such as solutions and suspensions. Most importantly, lipid nanoparticles were proven to be significantly superior to the polymeric counterparts.
format Online
Article
Text
id pubmed-9687115
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96871152022-11-25 Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers Hathout, Rania M. El-Marakby, Eman M. Bioengineering (Basel) Article Objectives: The intranasal route represents a high promising route of administration aiming for brain delivery. Yet, it represents one of the most difficult and complicated routes. Accordingly, scientists are in a continuous search for novel drug delivery vehicles such as the lipid and polymeric nanoparticles that are apt to enhance the bioavailability of the administered drugs to reach the brain. In this study, a certain number of publications were selected from different databases and literature. Meta-analysis studies using two different algorithms (DerSimonian–Laird and inverse variance) followed aiming to explore the published studies and confirm by evidence the superiority of nanocarriers in enhancing the brain bioavailability of various drugs. Furthermore, the quantitative comparison of lipid versus polymeric nanosystems was performed. Methods: The area under the curve (AUC) as an important pharmacokinetic parameter extracted from in vivo animal studies was designated as the “effect” in the performed meta-analysis after normalization. Forest plots were generated. Key findings and Conclusions: The meta-analysis confirmed the augmentation of the AUC after the comparison with traditional preparations such as solutions and suspensions. Most importantly, lipid nanoparticles were proven to be significantly superior to the polymeric counterparts. MDPI 2022-11-03 /pmc/articles/PMC9687115/ /pubmed/36354558 http://dx.doi.org/10.3390/bioengineering9110647 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hathout, Rania M.
El-Marakby, Eman M.
Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers
title Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers
title_full Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers
title_fullStr Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers
title_full_unstemmed Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers
title_short Meta-Analysis: A Convenient Tool for the Choice of Nose-to-Brain Nanocarriers
title_sort meta-analysis: a convenient tool for the choice of nose-to-brain nanocarriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687115/
https://www.ncbi.nlm.nih.gov/pubmed/36354558
http://dx.doi.org/10.3390/bioengineering9110647
work_keys_str_mv AT hathoutraniam metaanalysisaconvenienttoolforthechoiceofnosetobrainnanocarriers
AT elmarakbyemanm metaanalysisaconvenienttoolforthechoiceofnosetobrainnanocarriers