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Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis

Chronic kidney disease (CKD) and chronic periodontitis (CP) contribute to the increased level of inflammatory biomarkers in the blood. This study hypothesized that successful periodontal treatment would reduce the level of inflammatory biomarkers in CKD patients. This prospective study recruited two...

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Autores principales: Chaudhry, Ahmed, Kassim, Nur Karyatee, Zainuddin, Siti Lailatul Akmar, Taib, Haslina, Ibrahim, Hanim Afzan, Ahmad, Basaruddin, Hanafi, Muhammad Hafiz, Adnan, Azreen Syazril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687126/
https://www.ncbi.nlm.nih.gov/pubmed/36359271
http://dx.doi.org/10.3390/biomedicines10112752
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author Chaudhry, Ahmed
Kassim, Nur Karyatee
Zainuddin, Siti Lailatul Akmar
Taib, Haslina
Ibrahim, Hanim Afzan
Ahmad, Basaruddin
Hanafi, Muhammad Hafiz
Adnan, Azreen Syazril
author_facet Chaudhry, Ahmed
Kassim, Nur Karyatee
Zainuddin, Siti Lailatul Akmar
Taib, Haslina
Ibrahim, Hanim Afzan
Ahmad, Basaruddin
Hanafi, Muhammad Hafiz
Adnan, Azreen Syazril
author_sort Chaudhry, Ahmed
collection PubMed
description Chronic kidney disease (CKD) and chronic periodontitis (CP) contribute to the increased level of inflammatory biomarkers in the blood. This study hypothesized that successful periodontal treatment would reduce the level of inflammatory biomarkers in CKD patients. This prospective study recruited two groups of CP patients: 33 pre-dialysis CKD patients and 33 non-CKD patients. All patients underwent non-surgical periodontal therapy (NSPT). Their blood samples and periodontal parameters were taken before and after six weeks of NSPT. The serum level of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and periodontal parameters were compared between groups. On the other hand, kidney function indicators such as serum urea and estimated glomerular filtration rate (eGFR) were only measured in CKD patients. Clinical periodontal parameters and inflammatory markers levels at baseline were significantly higher (p < 0.05) in the CKD group than in the non-CKD group and showed significant reduction (p < 0.05) after six weeks of NSPT. CKD patients demonstrated a greater periodontitis severity and higher inflammatory burden than non-CKD patients. Additionally, CKD patients with CP showed a good response to NSPT. Therefore, CKD patients’ periodontal health needs to be screened for early dental interventions and monitored accordingly.
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spelling pubmed-96871262022-11-25 Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis Chaudhry, Ahmed Kassim, Nur Karyatee Zainuddin, Siti Lailatul Akmar Taib, Haslina Ibrahim, Hanim Afzan Ahmad, Basaruddin Hanafi, Muhammad Hafiz Adnan, Azreen Syazril Biomedicines Article Chronic kidney disease (CKD) and chronic periodontitis (CP) contribute to the increased level of inflammatory biomarkers in the blood. This study hypothesized that successful periodontal treatment would reduce the level of inflammatory biomarkers in CKD patients. This prospective study recruited two groups of CP patients: 33 pre-dialysis CKD patients and 33 non-CKD patients. All patients underwent non-surgical periodontal therapy (NSPT). Their blood samples and periodontal parameters were taken before and after six weeks of NSPT. The serum level of high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and periodontal parameters were compared between groups. On the other hand, kidney function indicators such as serum urea and estimated glomerular filtration rate (eGFR) were only measured in CKD patients. Clinical periodontal parameters and inflammatory markers levels at baseline were significantly higher (p < 0.05) in the CKD group than in the non-CKD group and showed significant reduction (p < 0.05) after six weeks of NSPT. CKD patients demonstrated a greater periodontitis severity and higher inflammatory burden than non-CKD patients. Additionally, CKD patients with CP showed a good response to NSPT. Therefore, CKD patients’ periodontal health needs to be screened for early dental interventions and monitored accordingly. MDPI 2022-10-29 /pmc/articles/PMC9687126/ /pubmed/36359271 http://dx.doi.org/10.3390/biomedicines10112752 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chaudhry, Ahmed
Kassim, Nur Karyatee
Zainuddin, Siti Lailatul Akmar
Taib, Haslina
Ibrahim, Hanim Afzan
Ahmad, Basaruddin
Hanafi, Muhammad Hafiz
Adnan, Azreen Syazril
Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis
title Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis
title_full Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis
title_fullStr Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis
title_full_unstemmed Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis
title_short Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis
title_sort potential effects of non-surgical periodontal therapy on periodontal parameters, inflammatory markers, and kidney function indicators in chronic kidney disease patients with chronic periodontitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687126/
https://www.ncbi.nlm.nih.gov/pubmed/36359271
http://dx.doi.org/10.3390/biomedicines10112752
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