Identification of NRAS Downstream Genes with CRISPR Activation Screening

SIMPLE SUMMARY: NRAS mutations constitutively activate cell proliferation signaling in malignant tumors. The elucidation of NRAS downstream signaling genes may lead to the control of NRAS-mutant tumors. Genome-wide CRISPR activation screening was performed on THP-1 B11, in which NRAS expression and...

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Detalles Bibliográficos
Autores principales: Tatsumi, Akiya, Hirakochi, Haruka, Inoue, Satomi, Tanaka, Yosuke, Furuno, Hidehiro, Ikeda, Masumi, Ishibashi, Sachiko, Taguchi, Towako, Yamamoto, Kouhei, Onishi, Iichiroh, Sachs, Zohar, Largaespada, David A., Kitagawa, Masanobu, Kurata, Morito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687188/
https://www.ncbi.nlm.nih.gov/pubmed/36358254
http://dx.doi.org/10.3390/biology11111551

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