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Profibrotic Effects of Endothelin-1 on Fibroblasts Are Mediated by Aldosterone In Vitro: Relevance to the Pathogenesis and Therapy of Systemic Sclerosis and Pulmonary Arterial Hypertension

Endothelin-1 (ET-1) is a vasoactive and profibrotic peptide that plays a pivotal role in diseases such as systemic sclerosis (SSc) and pulmonary arterial hypertension (PAH), by inducing fibrosis and vascular remodeling. Such effects may be sustained by the induction of aldosterone production and rea...

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Detalles Bibliográficos
Autores principales:	Argentino, Giuseppe, Barbieri, Alessandro, Beri, Ruggero, Bason, Caterina, Ruzzenente, Andrea, Olivieri, Oliviero, Tinazzi, Elisa, Puccetti, Antonio, Vitali, Claudio, Del Papa, Nicoletta, Friso, Simonetta, Lunardi, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687242/ https://www.ncbi.nlm.nih.gov/pubmed/36359285 http://dx.doi.org/10.3390/biomedicines10112765

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