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The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population

Interstitial lung abnormalities (ILA) are defined as the presence of different patterns of increased lung density, including ground glass attenuation and reticular opacities on chest high-resolution computed tomography (HRCT). In this study, we included 90 subjects with ILA and 189 healthy controls...

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Autores principales: Buendia-Roldan, Ivette, Ponce-Gallegos, Marco Antonio, Lara-Beltrán, Daniela, Del Ángel-Pablo, Alma D., Pérez-Rubio, Gloria, Mejía, Mayra, Selman, Moises, Falfán-Valencia, Ramcés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687358/
https://www.ncbi.nlm.nih.gov/pubmed/36359012
http://dx.doi.org/10.3390/biom12111662
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author Buendia-Roldan, Ivette
Ponce-Gallegos, Marco Antonio
Lara-Beltrán, Daniela
Del Ángel-Pablo, Alma D.
Pérez-Rubio, Gloria
Mejía, Mayra
Selman, Moises
Falfán-Valencia, Ramcés
author_facet Buendia-Roldan, Ivette
Ponce-Gallegos, Marco Antonio
Lara-Beltrán, Daniela
Del Ángel-Pablo, Alma D.
Pérez-Rubio, Gloria
Mejía, Mayra
Selman, Moises
Falfán-Valencia, Ramcés
author_sort Buendia-Roldan, Ivette
collection PubMed
description Interstitial lung abnormalities (ILA) are defined as the presence of different patterns of increased lung density, including ground glass attenuation and reticular opacities on chest high-resolution computed tomography (HRCT). In this study, we included 90 subjects with ILA and 189 healthy controls (HC) from our Aging Lung Program. We found that subjects with ILA are older, have a significant smoking history, and have worse pulmonary function than HC (p < 0.05). When we evaluated the allele frequencies of the human leukocyte antigen (HLA) system, we found that HLA-DRB1*07 was associated with a higher risk for ILA (p < 0.05, OR = 1.95, 95% CI = 1.06–3.57). When we compared subjects with subpleural ILA vs. HC, the association with HLA-DRB1*07 became stronger than the whole ILA group (p < 0.05, OR = 2.29, 95% CI = 1.24–4.25). Furthermore, subjects with subpleural ILA and central ILA display differences in allele frequencies with HLA-DRB1*14 (3.33% vs. 13.33%, p < 0.05) and *15 (3.33% vs. 20%, p < 0.05). Our findings indicate that the HLA-DRB1*07 allele contributes to the risk of ILA, especially those of subpleural locations.
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spelling pubmed-96873582022-11-25 The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population Buendia-Roldan, Ivette Ponce-Gallegos, Marco Antonio Lara-Beltrán, Daniela Del Ángel-Pablo, Alma D. Pérez-Rubio, Gloria Mejía, Mayra Selman, Moises Falfán-Valencia, Ramcés Biomolecules Article Interstitial lung abnormalities (ILA) are defined as the presence of different patterns of increased lung density, including ground glass attenuation and reticular opacities on chest high-resolution computed tomography (HRCT). In this study, we included 90 subjects with ILA and 189 healthy controls (HC) from our Aging Lung Program. We found that subjects with ILA are older, have a significant smoking history, and have worse pulmonary function than HC (p < 0.05). When we evaluated the allele frequencies of the human leukocyte antigen (HLA) system, we found that HLA-DRB1*07 was associated with a higher risk for ILA (p < 0.05, OR = 1.95, 95% CI = 1.06–3.57). When we compared subjects with subpleural ILA vs. HC, the association with HLA-DRB1*07 became stronger than the whole ILA group (p < 0.05, OR = 2.29, 95% CI = 1.24–4.25). Furthermore, subjects with subpleural ILA and central ILA display differences in allele frequencies with HLA-DRB1*14 (3.33% vs. 13.33%, p < 0.05) and *15 (3.33% vs. 20%, p < 0.05). Our findings indicate that the HLA-DRB1*07 allele contributes to the risk of ILA, especially those of subpleural locations. MDPI 2022-11-09 /pmc/articles/PMC9687358/ /pubmed/36359012 http://dx.doi.org/10.3390/biom12111662 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Buendia-Roldan, Ivette
Ponce-Gallegos, Marco Antonio
Lara-Beltrán, Daniela
Del Ángel-Pablo, Alma D.
Pérez-Rubio, Gloria
Mejía, Mayra
Selman, Moises
Falfán-Valencia, Ramcés
The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population
title The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population
title_full The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population
title_fullStr The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population
title_full_unstemmed The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population
title_short The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population
title_sort hla-drb1*07 allele is associated with interstitial lung abnormalities (ila) and subpleural location in a mexican mestizo population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687358/
https://www.ncbi.nlm.nih.gov/pubmed/36359012
http://dx.doi.org/10.3390/biom12111662
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