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The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population
Interstitial lung abnormalities (ILA) are defined as the presence of different patterns of increased lung density, including ground glass attenuation and reticular opacities on chest high-resolution computed tomography (HRCT). In this study, we included 90 subjects with ILA and 189 healthy controls...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687358/ https://www.ncbi.nlm.nih.gov/pubmed/36359012 http://dx.doi.org/10.3390/biom12111662 |
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author | Buendia-Roldan, Ivette Ponce-Gallegos, Marco Antonio Lara-Beltrán, Daniela Del Ángel-Pablo, Alma D. Pérez-Rubio, Gloria Mejía, Mayra Selman, Moises Falfán-Valencia, Ramcés |
author_facet | Buendia-Roldan, Ivette Ponce-Gallegos, Marco Antonio Lara-Beltrán, Daniela Del Ángel-Pablo, Alma D. Pérez-Rubio, Gloria Mejía, Mayra Selman, Moises Falfán-Valencia, Ramcés |
author_sort | Buendia-Roldan, Ivette |
collection | PubMed |
description | Interstitial lung abnormalities (ILA) are defined as the presence of different patterns of increased lung density, including ground glass attenuation and reticular opacities on chest high-resolution computed tomography (HRCT). In this study, we included 90 subjects with ILA and 189 healthy controls (HC) from our Aging Lung Program. We found that subjects with ILA are older, have a significant smoking history, and have worse pulmonary function than HC (p < 0.05). When we evaluated the allele frequencies of the human leukocyte antigen (HLA) system, we found that HLA-DRB1*07 was associated with a higher risk for ILA (p < 0.05, OR = 1.95, 95% CI = 1.06–3.57). When we compared subjects with subpleural ILA vs. HC, the association with HLA-DRB1*07 became stronger than the whole ILA group (p < 0.05, OR = 2.29, 95% CI = 1.24–4.25). Furthermore, subjects with subpleural ILA and central ILA display differences in allele frequencies with HLA-DRB1*14 (3.33% vs. 13.33%, p < 0.05) and *15 (3.33% vs. 20%, p < 0.05). Our findings indicate that the HLA-DRB1*07 allele contributes to the risk of ILA, especially those of subpleural locations. |
format | Online Article Text |
id | pubmed-9687358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96873582022-11-25 The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population Buendia-Roldan, Ivette Ponce-Gallegos, Marco Antonio Lara-Beltrán, Daniela Del Ángel-Pablo, Alma D. Pérez-Rubio, Gloria Mejía, Mayra Selman, Moises Falfán-Valencia, Ramcés Biomolecules Article Interstitial lung abnormalities (ILA) are defined as the presence of different patterns of increased lung density, including ground glass attenuation and reticular opacities on chest high-resolution computed tomography (HRCT). In this study, we included 90 subjects with ILA and 189 healthy controls (HC) from our Aging Lung Program. We found that subjects with ILA are older, have a significant smoking history, and have worse pulmonary function than HC (p < 0.05). When we evaluated the allele frequencies of the human leukocyte antigen (HLA) system, we found that HLA-DRB1*07 was associated with a higher risk for ILA (p < 0.05, OR = 1.95, 95% CI = 1.06–3.57). When we compared subjects with subpleural ILA vs. HC, the association with HLA-DRB1*07 became stronger than the whole ILA group (p < 0.05, OR = 2.29, 95% CI = 1.24–4.25). Furthermore, subjects with subpleural ILA and central ILA display differences in allele frequencies with HLA-DRB1*14 (3.33% vs. 13.33%, p < 0.05) and *15 (3.33% vs. 20%, p < 0.05). Our findings indicate that the HLA-DRB1*07 allele contributes to the risk of ILA, especially those of subpleural locations. MDPI 2022-11-09 /pmc/articles/PMC9687358/ /pubmed/36359012 http://dx.doi.org/10.3390/biom12111662 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Buendia-Roldan, Ivette Ponce-Gallegos, Marco Antonio Lara-Beltrán, Daniela Del Ángel-Pablo, Alma D. Pérez-Rubio, Gloria Mejía, Mayra Selman, Moises Falfán-Valencia, Ramcés The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population |
title | The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population |
title_full | The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population |
title_fullStr | The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population |
title_full_unstemmed | The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population |
title_short | The HLA-DRB1*07 Allele Is Associated with Interstitial Lung Abnormalities (ILA) and Subpleural Location in a Mexican Mestizo Population |
title_sort | hla-drb1*07 allele is associated with interstitial lung abnormalities (ila) and subpleural location in a mexican mestizo population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687358/ https://www.ncbi.nlm.nih.gov/pubmed/36359012 http://dx.doi.org/10.3390/biom12111662 |
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