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Wound Healing versus Metastasis: Role of Oxidative Stress

Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophage...

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Autores principales: Lopez, Tatiana, Wendremaire, Maeva, Lagarde, Jimmy, Duquet, Oriane, Alibert, Line, Paquette, Brice, Garrido, Carmen, Lirussi, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687595/
https://www.ncbi.nlm.nih.gov/pubmed/36359304
http://dx.doi.org/10.3390/biomedicines10112784
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author Lopez, Tatiana
Wendremaire, Maeva
Lagarde, Jimmy
Duquet, Oriane
Alibert, Line
Paquette, Brice
Garrido, Carmen
Lirussi, Frédéric
author_facet Lopez, Tatiana
Wendremaire, Maeva
Lagarde, Jimmy
Duquet, Oriane
Alibert, Line
Paquette, Brice
Garrido, Carmen
Lirussi, Frédéric
author_sort Lopez, Tatiana
collection PubMed
description Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophages-released ROS arise as major regulators of these processes. But, whatever the pathology concerned, oxidative stress is a complicated phenomenon to control and requires a finely tuned balance over the different stages and responding cells. This review provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, encompassing the contribution of macrophages. Indeed, macrophages are major ROS producers but also appear as their targets since ROS interfere with their differentiation and function. Elucidating ROS functions in wound healing and metastatic spread may allow the development of innovative therapeutic strategies involving redox modulators.
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spelling pubmed-96875952022-11-25 Wound Healing versus Metastasis: Role of Oxidative Stress Lopez, Tatiana Wendremaire, Maeva Lagarde, Jimmy Duquet, Oriane Alibert, Line Paquette, Brice Garrido, Carmen Lirussi, Frédéric Biomedicines Review Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophages-released ROS arise as major regulators of these processes. But, whatever the pathology concerned, oxidative stress is a complicated phenomenon to control and requires a finely tuned balance over the different stages and responding cells. This review provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, encompassing the contribution of macrophages. Indeed, macrophages are major ROS producers but also appear as their targets since ROS interfere with their differentiation and function. Elucidating ROS functions in wound healing and metastatic spread may allow the development of innovative therapeutic strategies involving redox modulators. MDPI 2022-11-02 /pmc/articles/PMC9687595/ /pubmed/36359304 http://dx.doi.org/10.3390/biomedicines10112784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lopez, Tatiana
Wendremaire, Maeva
Lagarde, Jimmy
Duquet, Oriane
Alibert, Line
Paquette, Brice
Garrido, Carmen
Lirussi, Frédéric
Wound Healing versus Metastasis: Role of Oxidative Stress
title Wound Healing versus Metastasis: Role of Oxidative Stress
title_full Wound Healing versus Metastasis: Role of Oxidative Stress
title_fullStr Wound Healing versus Metastasis: Role of Oxidative Stress
title_full_unstemmed Wound Healing versus Metastasis: Role of Oxidative Stress
title_short Wound Healing versus Metastasis: Role of Oxidative Stress
title_sort wound healing versus metastasis: role of oxidative stress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687595/
https://www.ncbi.nlm.nih.gov/pubmed/36359304
http://dx.doi.org/10.3390/biomedicines10112784
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