Cargando…
Wound Healing versus Metastasis: Role of Oxidative Stress
Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophage...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687595/ https://www.ncbi.nlm.nih.gov/pubmed/36359304 http://dx.doi.org/10.3390/biomedicines10112784 |
_version_ | 1784836045700857856 |
---|---|
author | Lopez, Tatiana Wendremaire, Maeva Lagarde, Jimmy Duquet, Oriane Alibert, Line Paquette, Brice Garrido, Carmen Lirussi, Frédéric |
author_facet | Lopez, Tatiana Wendremaire, Maeva Lagarde, Jimmy Duquet, Oriane Alibert, Line Paquette, Brice Garrido, Carmen Lirussi, Frédéric |
author_sort | Lopez, Tatiana |
collection | PubMed |
description | Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophages-released ROS arise as major regulators of these processes. But, whatever the pathology concerned, oxidative stress is a complicated phenomenon to control and requires a finely tuned balance over the different stages and responding cells. This review provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, encompassing the contribution of macrophages. Indeed, macrophages are major ROS producers but also appear as their targets since ROS interfere with their differentiation and function. Elucidating ROS functions in wound healing and metastatic spread may allow the development of innovative therapeutic strategies involving redox modulators. |
format | Online Article Text |
id | pubmed-9687595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96875952022-11-25 Wound Healing versus Metastasis: Role of Oxidative Stress Lopez, Tatiana Wendremaire, Maeva Lagarde, Jimmy Duquet, Oriane Alibert, Line Paquette, Brice Garrido, Carmen Lirussi, Frédéric Biomedicines Review Many signaling pathways, molecular and cellular actors which are critical for wound healing have been implicated in cancer metastasis. These two conditions are a complex succession of cellular biological events and accurate regulation of these events is essential. Apart from inflammation, macrophages-released ROS arise as major regulators of these processes. But, whatever the pathology concerned, oxidative stress is a complicated phenomenon to control and requires a finely tuned balance over the different stages and responding cells. This review provides an overview of the pivotal role of oxidative stress in both wound healing and metastasis, encompassing the contribution of macrophages. Indeed, macrophages are major ROS producers but also appear as their targets since ROS interfere with their differentiation and function. Elucidating ROS functions in wound healing and metastatic spread may allow the development of innovative therapeutic strategies involving redox modulators. MDPI 2022-11-02 /pmc/articles/PMC9687595/ /pubmed/36359304 http://dx.doi.org/10.3390/biomedicines10112784 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lopez, Tatiana Wendremaire, Maeva Lagarde, Jimmy Duquet, Oriane Alibert, Line Paquette, Brice Garrido, Carmen Lirussi, Frédéric Wound Healing versus Metastasis: Role of Oxidative Stress |
title | Wound Healing versus Metastasis: Role of Oxidative Stress |
title_full | Wound Healing versus Metastasis: Role of Oxidative Stress |
title_fullStr | Wound Healing versus Metastasis: Role of Oxidative Stress |
title_full_unstemmed | Wound Healing versus Metastasis: Role of Oxidative Stress |
title_short | Wound Healing versus Metastasis: Role of Oxidative Stress |
title_sort | wound healing versus metastasis: role of oxidative stress |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687595/ https://www.ncbi.nlm.nih.gov/pubmed/36359304 http://dx.doi.org/10.3390/biomedicines10112784 |
work_keys_str_mv | AT lopeztatiana woundhealingversusmetastasisroleofoxidativestress AT wendremairemaeva woundhealingversusmetastasisroleofoxidativestress AT lagardejimmy woundhealingversusmetastasisroleofoxidativestress AT duquetoriane woundhealingversusmetastasisroleofoxidativestress AT alibertline woundhealingversusmetastasisroleofoxidativestress AT paquettebrice woundhealingversusmetastasisroleofoxidativestress AT garridocarmen woundhealingversusmetastasisroleofoxidativestress AT lirussifrederic woundhealingversusmetastasisroleofoxidativestress |