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Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps

Despite the heterogeneity of chronic rhinosinusitis (CRS), a clear link exists between type 2 immunity and the severity of CRS with nasal polyps (CRSwNP). However, recent studies have demonstrated that patients with severe type 2 CRSwNP also display abundant neutrophilic inflammation. Therefore, we...

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Autores principales: Yu, Hyunjae, Kim, Dong-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687645/
https://www.ncbi.nlm.nih.gov/pubmed/36428479
http://dx.doi.org/10.3390/biomedicines10112911
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author Yu, Hyunjae
Kim, Dong-Kyu
author_facet Yu, Hyunjae
Kim, Dong-Kyu
author_sort Yu, Hyunjae
collection PubMed
description Despite the heterogeneity of chronic rhinosinusitis (CRS), a clear link exists between type 2 immunity and the severity of CRS with nasal polyps (CRSwNP). However, recent studies have demonstrated that patients with severe type 2 CRSwNP also display abundant neutrophilic inflammation. Therefore, we investigated the factors associated with the recurrence of CRSwNP following sinus surgery using a machine-learning algorithm. We collected the demographics, clinical variables, and inflammatory profiles of 210 patients with CRSwNP who underwent sinus surgery. After one year, we evaluated whether each patient showed recurrence. Machine-learning methods, such as decision trees, random forests, and support vector machine models, have been used to predict the recurrence of CRSwNP. The results indicated that neutrophil inflammation, such as tissue and serum neutrophils, is an important factor affecting the recurrence of surgical CRSwNP. Specifically, the random forest model showed the highest accuracy in detecting recurrence among the three machine-learning methods, which revealed tissue neutrophilia to be the most important variable in determining surgical outcomes. Therefore, our machine-learning approach suggests that neutrophilic inflammation is increased in patients with difficult-to-treat CRSwNP, and the increased presence of neutrophils in subepithelial regions is closely related to poor surgical outcomes in patients with CRSwNP.
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spelling pubmed-96876452022-11-25 Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps Yu, Hyunjae Kim, Dong-Kyu Biomedicines Article Despite the heterogeneity of chronic rhinosinusitis (CRS), a clear link exists between type 2 immunity and the severity of CRS with nasal polyps (CRSwNP). However, recent studies have demonstrated that patients with severe type 2 CRSwNP also display abundant neutrophilic inflammation. Therefore, we investigated the factors associated with the recurrence of CRSwNP following sinus surgery using a machine-learning algorithm. We collected the demographics, clinical variables, and inflammatory profiles of 210 patients with CRSwNP who underwent sinus surgery. After one year, we evaluated whether each patient showed recurrence. Machine-learning methods, such as decision trees, random forests, and support vector machine models, have been used to predict the recurrence of CRSwNP. The results indicated that neutrophil inflammation, such as tissue and serum neutrophils, is an important factor affecting the recurrence of surgical CRSwNP. Specifically, the random forest model showed the highest accuracy in detecting recurrence among the three machine-learning methods, which revealed tissue neutrophilia to be the most important variable in determining surgical outcomes. Therefore, our machine-learning approach suggests that neutrophilic inflammation is increased in patients with difficult-to-treat CRSwNP, and the increased presence of neutrophils in subepithelial regions is closely related to poor surgical outcomes in patients with CRSwNP. MDPI 2022-11-12 /pmc/articles/PMC9687645/ /pubmed/36428479 http://dx.doi.org/10.3390/biomedicines10112911 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Hyunjae
Kim, Dong-Kyu
Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps
title Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps
title_full Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps
title_fullStr Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps
title_full_unstemmed Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps
title_short Neutrophils Play an Important Role in the Recurrence of Chronic Rhinosinusitis with Nasal Polyps
title_sort neutrophils play an important role in the recurrence of chronic rhinosinusitis with nasal polyps
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687645/
https://www.ncbi.nlm.nih.gov/pubmed/36428479
http://dx.doi.org/10.3390/biomedicines10112911
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