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Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction

This study aimed to investigate the relationship between the lymph node ratio (LNR) and survival results of patients with head and neck squamous cell carcinoma (HNSCC) reconstructed by a submental artery flap (SMAF) to limit tumor size. This study retrospectively recruited 49 patients with HNSCC who...

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Autores principales: Suzuki, Hidenori, Beppu, Shintaro, Nishikawa, Daisuke, Terada, Hoshino, Sawabe, Michi, Hanai, Nobuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687667/
https://www.ncbi.nlm.nih.gov/pubmed/36428496
http://dx.doi.org/10.3390/biomedicines10112923
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author Suzuki, Hidenori
Beppu, Shintaro
Nishikawa, Daisuke
Terada, Hoshino
Sawabe, Michi
Hanai, Nobuhiro
author_facet Suzuki, Hidenori
Beppu, Shintaro
Nishikawa, Daisuke
Terada, Hoshino
Sawabe, Michi
Hanai, Nobuhiro
author_sort Suzuki, Hidenori
collection PubMed
description This study aimed to investigate the relationship between the lymph node ratio (LNR) and survival results of patients with head and neck squamous cell carcinoma (HNSCC) reconstructed by a submental artery flap (SMAF) to limit tumor size. This study retrospectively recruited 49 patients with HNSCC who underwent both primary resection and neck dissection with SMAF reconstruction. The LNR was the ratio of the number of metastatic lymph nodes to the sum number of examined lymph nodes. A LNR of 0.04 was the best cut-off value for HNSCC-specific death on receiver operating curve analysis. Patients with LNRs > 0.04 were univariately related to cancer-specific, disease-free, distant metastasis-free, and locoregional recurrence-free survival than those with LNRs ≤ 0.04 by log-rank test. In a Cox’s proportional hazards model with hazard ratio (HR) and 95% confidence interval (CI) adjusting for pathological stage, extranodal extension and or surgical margins, the LNR (>0.04/≤0.04) predicted multivariate shorter cancer-specific (HR = 9.24, 95% CI = 1.49–176), disease-free (HR = 3.44, 95% CI = 1.23–10.3), and distant metastasis-free (HR = 9.76, 95% CI = 1.57–187) survival. In conclusion, LNR for patients of HNSCC with SMAF reconstruction for limited tumor size was a prognostic factor for survival outcomes.
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spelling pubmed-96876672022-11-25 Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction Suzuki, Hidenori Beppu, Shintaro Nishikawa, Daisuke Terada, Hoshino Sawabe, Michi Hanai, Nobuhiro Biomedicines Communication This study aimed to investigate the relationship between the lymph node ratio (LNR) and survival results of patients with head and neck squamous cell carcinoma (HNSCC) reconstructed by a submental artery flap (SMAF) to limit tumor size. This study retrospectively recruited 49 patients with HNSCC who underwent both primary resection and neck dissection with SMAF reconstruction. The LNR was the ratio of the number of metastatic lymph nodes to the sum number of examined lymph nodes. A LNR of 0.04 was the best cut-off value for HNSCC-specific death on receiver operating curve analysis. Patients with LNRs > 0.04 were univariately related to cancer-specific, disease-free, distant metastasis-free, and locoregional recurrence-free survival than those with LNRs ≤ 0.04 by log-rank test. In a Cox’s proportional hazards model with hazard ratio (HR) and 95% confidence interval (CI) adjusting for pathological stage, extranodal extension and or surgical margins, the LNR (>0.04/≤0.04) predicted multivariate shorter cancer-specific (HR = 9.24, 95% CI = 1.49–176), disease-free (HR = 3.44, 95% CI = 1.23–10.3), and distant metastasis-free (HR = 9.76, 95% CI = 1.57–187) survival. In conclusion, LNR for patients of HNSCC with SMAF reconstruction for limited tumor size was a prognostic factor for survival outcomes. MDPI 2022-11-14 /pmc/articles/PMC9687667/ /pubmed/36428496 http://dx.doi.org/10.3390/biomedicines10112923 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Suzuki, Hidenori
Beppu, Shintaro
Nishikawa, Daisuke
Terada, Hoshino
Sawabe, Michi
Hanai, Nobuhiro
Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction
title Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction
title_full Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction
title_fullStr Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction
title_full_unstemmed Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction
title_short Lymph Node Ratio in Head and Neck Cancer with Submental Flap Reconstruction
title_sort lymph node ratio in head and neck cancer with submental flap reconstruction
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687667/
https://www.ncbi.nlm.nih.gov/pubmed/36428496
http://dx.doi.org/10.3390/biomedicines10112923
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