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Long-Term Blockade of Nociceptive Na(v)1.7 Channels Is Analgesic in Rat Models of Knee Arthritis

The voltage gated sodium channels (Na(v)) 1.7, 1.8, and 1.9 are primarily located on nociceptors where they are involved in signalling neuropathic pain. This study examined the effect of Na(v)1.7 blockade on joint pain using either the small molecule inhibitor PF05089771 or an antibody directed towa...

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Detalles Bibliográficos
Autores principales:	Reid, Allison R., Côté, Patrice D., McDougall, Jason J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687684/ https://www.ncbi.nlm.nih.gov/pubmed/36358921 http://dx.doi.org/10.3390/biom12111571

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