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NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features
Background: The aim of this study was to determine the frequency of the rs738409 polymorphism in the patatin-like phospholipase domain containing 3 (PNPLA3) gene in patients with polycystic ovary syndrome (PCOS) and its impact on nonalcoholic fatty liver disease (NAFLD) risk and severity. We also ev...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687705/ https://www.ncbi.nlm.nih.gov/pubmed/36359239 http://dx.doi.org/10.3390/biomedicines10112719 |
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author | Recuero, Amanda Medeiros Gomes, Larissa Garcia Maciel, Gustavo Arantes Rosa de Mello Malta, Fernanda Salles, Ana Paula Moreira Vezozzo, Denise Cerqueira Paranaguá Baracat, Edmund Chada Pinho, João Renato Rebello Carrilho, Flair José Stefano, José Tadeu Oliveira, Claudia P. |
author_facet | Recuero, Amanda Medeiros Gomes, Larissa Garcia Maciel, Gustavo Arantes Rosa de Mello Malta, Fernanda Salles, Ana Paula Moreira Vezozzo, Denise Cerqueira Paranaguá Baracat, Edmund Chada Pinho, João Renato Rebello Carrilho, Flair José Stefano, José Tadeu Oliveira, Claudia P. |
author_sort | Recuero, Amanda Medeiros |
collection | PubMed |
description | Background: The aim of this study was to determine the frequency of the rs738409 polymorphism in the patatin-like phospholipase domain containing 3 (PNPLA3) gene in patients with polycystic ovary syndrome (PCOS) and its impact on nonalcoholic fatty liver disease (NAFLD) risk and severity. We also evaluated other risk factors associated with NAFLD and advanced fibrosis. Methods: This was a cross-sectional study involving 163 patients with PCOS at a tertiary center. Genotyping for the PNPLA3 polymorphism was undertaken using a TaqMan assay. The degree of fibrosis was defined by transient elastography. Results: The prevalence of NAFLD was 72.4%, and the polymorphism was heterozygous in 41.7% and homozygous in 8% of patients. Homeostasis model assessment of insulin resistance ≥ 2.5 was the main factor associated with the risk of developing NAFLD (OR = 4.313, p = 0.022), and its effect was amplified by the polymorphism (OR = 12.198, p = 0.017). Age > 32 years also conferred a higher risk for NAFLD. HDL values ≥ 50 mg/dL conferred protection against the outcome. Metabolic syndrome (OR = 13.030, p = 0.020) and AST > 32 U/L (OR = 9.039, p = 0.009) were independent risk factors for advanced fibrosis. Conclusions: In women with PCOS, metabolic characteristics are more relevant than PNPLA3 polymorphism regarding the risk for NAFLD and its advanced forms, but these factors can act synergistically, increasing disease risk. |
format | Online Article Text |
id | pubmed-9687705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96877052022-11-25 NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features Recuero, Amanda Medeiros Gomes, Larissa Garcia Maciel, Gustavo Arantes Rosa de Mello Malta, Fernanda Salles, Ana Paula Moreira Vezozzo, Denise Cerqueira Paranaguá Baracat, Edmund Chada Pinho, João Renato Rebello Carrilho, Flair José Stefano, José Tadeu Oliveira, Claudia P. Biomedicines Article Background: The aim of this study was to determine the frequency of the rs738409 polymorphism in the patatin-like phospholipase domain containing 3 (PNPLA3) gene in patients with polycystic ovary syndrome (PCOS) and its impact on nonalcoholic fatty liver disease (NAFLD) risk and severity. We also evaluated other risk factors associated with NAFLD and advanced fibrosis. Methods: This was a cross-sectional study involving 163 patients with PCOS at a tertiary center. Genotyping for the PNPLA3 polymorphism was undertaken using a TaqMan assay. The degree of fibrosis was defined by transient elastography. Results: The prevalence of NAFLD was 72.4%, and the polymorphism was heterozygous in 41.7% and homozygous in 8% of patients. Homeostasis model assessment of insulin resistance ≥ 2.5 was the main factor associated with the risk of developing NAFLD (OR = 4.313, p = 0.022), and its effect was amplified by the polymorphism (OR = 12.198, p = 0.017). Age > 32 years also conferred a higher risk for NAFLD. HDL values ≥ 50 mg/dL conferred protection against the outcome. Metabolic syndrome (OR = 13.030, p = 0.020) and AST > 32 U/L (OR = 9.039, p = 0.009) were independent risk factors for advanced fibrosis. Conclusions: In women with PCOS, metabolic characteristics are more relevant than PNPLA3 polymorphism regarding the risk for NAFLD and its advanced forms, but these factors can act synergistically, increasing disease risk. MDPI 2022-10-27 /pmc/articles/PMC9687705/ /pubmed/36359239 http://dx.doi.org/10.3390/biomedicines10112719 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Recuero, Amanda Medeiros Gomes, Larissa Garcia Maciel, Gustavo Arantes Rosa de Mello Malta, Fernanda Salles, Ana Paula Moreira Vezozzo, Denise Cerqueira Paranaguá Baracat, Edmund Chada Pinho, João Renato Rebello Carrilho, Flair José Stefano, José Tadeu Oliveira, Claudia P. NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features |
title | NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features |
title_full | NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features |
title_fullStr | NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features |
title_full_unstemmed | NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features |
title_short | NAFLD in Polycystic Ovary Syndrome: Association with PNPLA3 and Metabolic Features |
title_sort | nafld in polycystic ovary syndrome: association with pnpla3 and metabolic features |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687705/ https://www.ncbi.nlm.nih.gov/pubmed/36359239 http://dx.doi.org/10.3390/biomedicines10112719 |
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