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The Role of CYP3A in Health and Disease

CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); alm...

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Autores principales: Klyushova, Lyubov S., Perepechaeva, Maria L., Grishanova, Alevtina Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687714/
https://www.ncbi.nlm.nih.gov/pubmed/36359206
http://dx.doi.org/10.3390/biomedicines10112686
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author Klyushova, Lyubov S.
Perepechaeva, Maria L.
Grishanova, Alevtina Y.
author_facet Klyushova, Lyubov S.
Perepechaeva, Maria L.
Grishanova, Alevtina Y.
author_sort Klyushova, Lyubov S.
collection PubMed
description CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); almost the only common characteristic of these compounds is lipophilicity and a relatively large molecular weight. CYP3A enzymes are widely expressed in human organs and tissues, and consequences of these enzymes’ activities play a major role both in normal regulation of physiological levels of endogenous compounds and in various pathological conditions. This review addresses these aspects of regulation of CYP3A enzymes under physiological conditions and their involvement in the initiation and progression of diseases.
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spelling pubmed-96877142022-11-25 The Role of CYP3A in Health and Disease Klyushova, Lyubov S. Perepechaeva, Maria L. Grishanova, Alevtina Y. Biomedicines Review CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate toward substrates and are unique in that these enzymes metabolize both endogenous compounds and diverse xenobiotics (including drugs); almost the only common characteristic of these compounds is lipophilicity and a relatively large molecular weight. CYP3A enzymes are widely expressed in human organs and tissues, and consequences of these enzymes’ activities play a major role both in normal regulation of physiological levels of endogenous compounds and in various pathological conditions. This review addresses these aspects of regulation of CYP3A enzymes under physiological conditions and their involvement in the initiation and progression of diseases. MDPI 2022-10-24 /pmc/articles/PMC9687714/ /pubmed/36359206 http://dx.doi.org/10.3390/biomedicines10112686 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Klyushova, Lyubov S.
Perepechaeva, Maria L.
Grishanova, Alevtina Y.
The Role of CYP3A in Health and Disease
title The Role of CYP3A in Health and Disease
title_full The Role of CYP3A in Health and Disease
title_fullStr The Role of CYP3A in Health and Disease
title_full_unstemmed The Role of CYP3A in Health and Disease
title_short The Role of CYP3A in Health and Disease
title_sort role of cyp3a in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687714/
https://www.ncbi.nlm.nih.gov/pubmed/36359206
http://dx.doi.org/10.3390/biomedicines10112686
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