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Association of Pain Phenotypes with Risk of Falls and Incident Fractures

Objective: To compare whether falls risk score and incident fracture over 10.7 years were different among three previously identified pain phenotypes. Methods: Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at baseline and follow-ups at 2.6, 5.1 and 10...

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Autores principales: Devine, Maxim, Ma, Canchen, Tian, Jing, Antony, Benny, Cicuttini, Flavia, Jones, Graeme, Pan, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687743/
https://www.ncbi.nlm.nih.gov/pubmed/36428490
http://dx.doi.org/10.3390/biomedicines10112924
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author Devine, Maxim
Ma, Canchen
Tian, Jing
Antony, Benny
Cicuttini, Flavia
Jones, Graeme
Pan, Feng
author_facet Devine, Maxim
Ma, Canchen
Tian, Jing
Antony, Benny
Cicuttini, Flavia
Jones, Graeme
Pan, Feng
author_sort Devine, Maxim
collection PubMed
description Objective: To compare whether falls risk score and incident fracture over 10.7 years were different among three previously identified pain phenotypes. Methods: Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at baseline and follow-ups at 2.6, 5.1 and 10.7 years. Three pain phenotypes were previously identified using the latent class analysis: Class 1: high prevalence of emotional problems and low prevalence of structural damage; Class 2: high prevalence of structural damage and low prevalence of emotional problems; Class 3: low prevalence of emotional problems and low prevalence of structural damage. Fractures were self-reported and falls risk score was measured using the Physiological Profile Assessment. Generalized estimating equations model and linear mixed-effects model were used to compare differences in incident fractures and falls risk score over 10.7 years between pain phenotypes, respectively. Results: There were 3 new hip, 19 vertebral, and 121 non-vertebral fractures, and 138 any site fractures during 10.7-year follow-up. Compared with Class 3, Class 1 had a higher risk of vertebral (relative risk (RR) = 2.44, 95% CI: 1.22–4.91), non-vertebral fractures (RR = 1.20, 95% CI: 1.01–1.42), and any site fractures (RR = 1.24, 95% CI: 1.04–1.46) after controlling for covariates, bone mineral density and falls risk score. Class 2 had a higher risk of non-vertebral and any site fracture relative to those in Class 3 (non-vertebral: RR = 1.41, 95% CI: 1.17–1.71; any site: RR = 1.44, 95% CI: 1.20–1.73), but not vertebral fracture. Compared with Class 3, Class 1 had a higher falls risk score at baseline (β = 0.16, 95% CI: 0.09–0.23) and over 10.7-year (β = 0.03, 95% CI: 0.01–0.04). Conclusions: Class 1 and/or Class 2 had a higher risk of incident fractures and falls risk score than Class 3, highlighting that targeted preventive strategies for fractures and falls are needed in pain population.
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spelling pubmed-96877432022-11-25 Association of Pain Phenotypes with Risk of Falls and Incident Fractures Devine, Maxim Ma, Canchen Tian, Jing Antony, Benny Cicuttini, Flavia Jones, Graeme Pan, Feng Biomedicines Article Objective: To compare whether falls risk score and incident fracture over 10.7 years were different among three previously identified pain phenotypes. Methods: Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at baseline and follow-ups at 2.6, 5.1 and 10.7 years. Three pain phenotypes were previously identified using the latent class analysis: Class 1: high prevalence of emotional problems and low prevalence of structural damage; Class 2: high prevalence of structural damage and low prevalence of emotional problems; Class 3: low prevalence of emotional problems and low prevalence of structural damage. Fractures were self-reported and falls risk score was measured using the Physiological Profile Assessment. Generalized estimating equations model and linear mixed-effects model were used to compare differences in incident fractures and falls risk score over 10.7 years between pain phenotypes, respectively. Results: There were 3 new hip, 19 vertebral, and 121 non-vertebral fractures, and 138 any site fractures during 10.7-year follow-up. Compared with Class 3, Class 1 had a higher risk of vertebral (relative risk (RR) = 2.44, 95% CI: 1.22–4.91), non-vertebral fractures (RR = 1.20, 95% CI: 1.01–1.42), and any site fractures (RR = 1.24, 95% CI: 1.04–1.46) after controlling for covariates, bone mineral density and falls risk score. Class 2 had a higher risk of non-vertebral and any site fracture relative to those in Class 3 (non-vertebral: RR = 1.41, 95% CI: 1.17–1.71; any site: RR = 1.44, 95% CI: 1.20–1.73), but not vertebral fracture. Compared with Class 3, Class 1 had a higher falls risk score at baseline (β = 0.16, 95% CI: 0.09–0.23) and over 10.7-year (β = 0.03, 95% CI: 0.01–0.04). Conclusions: Class 1 and/or Class 2 had a higher risk of incident fractures and falls risk score than Class 3, highlighting that targeted preventive strategies for fractures and falls are needed in pain population. MDPI 2022-11-14 /pmc/articles/PMC9687743/ /pubmed/36428490 http://dx.doi.org/10.3390/biomedicines10112924 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Devine, Maxim
Ma, Canchen
Tian, Jing
Antony, Benny
Cicuttini, Flavia
Jones, Graeme
Pan, Feng
Association of Pain Phenotypes with Risk of Falls and Incident Fractures
title Association of Pain Phenotypes with Risk of Falls and Incident Fractures
title_full Association of Pain Phenotypes with Risk of Falls and Incident Fractures
title_fullStr Association of Pain Phenotypes with Risk of Falls and Incident Fractures
title_full_unstemmed Association of Pain Phenotypes with Risk of Falls and Incident Fractures
title_short Association of Pain Phenotypes with Risk of Falls and Incident Fractures
title_sort association of pain phenotypes with risk of falls and incident fractures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687743/
https://www.ncbi.nlm.nih.gov/pubmed/36428490
http://dx.doi.org/10.3390/biomedicines10112924
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