Discordant Amyloid Status Diagnosis in Alzheimer’s Disease
Introduction: Early and accurate Alzheimer’s disease (AD) diagnosis has evolved in recent years by the use of specific methods for detecting its histopathological features in concrete cases. Currently, biomarkers in cerebrospinal fluid (CSF) and imaging techniques (amyloid PET) are the most used spe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687806/ https://www.ncbi.nlm.nih.gov/pubmed/36359400 http://dx.doi.org/10.3390/biomedicines10112880 |
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author | García-Vallés, Lorena Peña-Bautista, Carmen Álvarez-Sánchez, Lourdes Ferrer-Cairols, Inés Baquero, Miguel Cháfer-Pericás, Consuelo |
author_facet | García-Vallés, Lorena Peña-Bautista, Carmen Álvarez-Sánchez, Lourdes Ferrer-Cairols, Inés Baquero, Miguel Cháfer-Pericás, Consuelo |
author_sort | García-Vallés, Lorena |
collection | PubMed |
description | Introduction: Early and accurate Alzheimer’s disease (AD) diagnosis has evolved in recent years by the use of specific methods for detecting its histopathological features in concrete cases. Currently, biomarkers in cerebrospinal fluid (CSF) and imaging techniques (amyloid PET) are the most used specific methods. However, some results between both methods are discrepant. Therefore, an evaluation of these discrepant cases is required. Objective: The aim of this work is to analyze the characteristics of cases showing discrepancies between methods for detecting amyloid pathology. Methodology: Patients from the Neurology Department of La Fe Hospital (n = 82) were diagnosed using both methods (CSF biomarkers and amyloid-PET). Statistical analyses were performed using logistic regression, and sex and age were included as covariables. Additionally, results of standard neuropsychological evaluations were taken into account in our analyses. Results: The comparison between CSF biomarker (Aβ42) and amyloid PET results showed that around 18% of cases were discrepant—mainly CFS-negative and PET-positive cases had CSF levels close to the cut-off point. In addition, a correlation between the episodic memory test and CSF biomarkers levels was observed. However, the same results were not obtained for other neuropsychological domains. In general, CSF- and PET-discrepant cases showed altered episodic memory in around 66% of cases, while 33% showed normal performance. Conclusions: In common clinical practice at tertiary memory centers, result discrepancies between tests of amyloid status are far more common than expected. However, episodic memory tests remain an important support method for AD diagnosis, especially in cases with discrepant results between amyloid PET and CSF biomarkers. |
format | Online Article Text |
id | pubmed-9687806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96878062022-11-25 Discordant Amyloid Status Diagnosis in Alzheimer’s Disease García-Vallés, Lorena Peña-Bautista, Carmen Álvarez-Sánchez, Lourdes Ferrer-Cairols, Inés Baquero, Miguel Cháfer-Pericás, Consuelo Biomedicines Article Introduction: Early and accurate Alzheimer’s disease (AD) diagnosis has evolved in recent years by the use of specific methods for detecting its histopathological features in concrete cases. Currently, biomarkers in cerebrospinal fluid (CSF) and imaging techniques (amyloid PET) are the most used specific methods. However, some results between both methods are discrepant. Therefore, an evaluation of these discrepant cases is required. Objective: The aim of this work is to analyze the characteristics of cases showing discrepancies between methods for detecting amyloid pathology. Methodology: Patients from the Neurology Department of La Fe Hospital (n = 82) were diagnosed using both methods (CSF biomarkers and amyloid-PET). Statistical analyses were performed using logistic regression, and sex and age were included as covariables. Additionally, results of standard neuropsychological evaluations were taken into account in our analyses. Results: The comparison between CSF biomarker (Aβ42) and amyloid PET results showed that around 18% of cases were discrepant—mainly CFS-negative and PET-positive cases had CSF levels close to the cut-off point. In addition, a correlation between the episodic memory test and CSF biomarkers levels was observed. However, the same results were not obtained for other neuropsychological domains. In general, CSF- and PET-discrepant cases showed altered episodic memory in around 66% of cases, while 33% showed normal performance. Conclusions: In common clinical practice at tertiary memory centers, result discrepancies between tests of amyloid status are far more common than expected. However, episodic memory tests remain an important support method for AD diagnosis, especially in cases with discrepant results between amyloid PET and CSF biomarkers. MDPI 2022-11-10 /pmc/articles/PMC9687806/ /pubmed/36359400 http://dx.doi.org/10.3390/biomedicines10112880 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article García-Vallés, Lorena Peña-Bautista, Carmen Álvarez-Sánchez, Lourdes Ferrer-Cairols, Inés Baquero, Miguel Cháfer-Pericás, Consuelo Discordant Amyloid Status Diagnosis in Alzheimer’s Disease |
title | Discordant Amyloid Status Diagnosis in Alzheimer’s Disease |
title_full | Discordant Amyloid Status Diagnosis in Alzheimer’s Disease |
title_fullStr | Discordant Amyloid Status Diagnosis in Alzheimer’s Disease |
title_full_unstemmed | Discordant Amyloid Status Diagnosis in Alzheimer’s Disease |
title_short | Discordant Amyloid Status Diagnosis in Alzheimer’s Disease |
title_sort | discordant amyloid status diagnosis in alzheimer’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687806/ https://www.ncbi.nlm.nih.gov/pubmed/36359400 http://dx.doi.org/10.3390/biomedicines10112880 |
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