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CircRNAs in Tumor Radioresistance
Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs’ leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discover...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687855/ https://www.ncbi.nlm.nih.gov/pubmed/36358938 http://dx.doi.org/10.3390/biom12111586 |
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author | Gao, Yining Gao, Jiawen Lin, Fei Wang, Ting Huo, Sitong Wu, Jiefang Zhou, Qi Zhang, Chao |
author_facet | Gao, Yining Gao, Jiawen Lin, Fei Wang, Ting Huo, Sitong Wu, Jiefang Zhou, Qi Zhang, Chao |
author_sort | Gao, Yining |
collection | PubMed |
description | Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs’ leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation, regulating host genes, and even being translated into proteins. As some tumor cells are no longer radiosensitive, tumor radioresistance has since become a challenge in treating tumors. In recent years, circRNAs are differentially expressed in tumor cells and can be used as biological markers of tumors. In addition, circRNAs can regulate the radiosensitivity of tumors. Here, we list the mechanisms of circRNAs in glioma, nasopharyngeal carcinoma, and non-small cell lung cancer; further, these studies also provide new ideas for the purposes of eliminating radioresistance in tumors. |
format | Online Article Text |
id | pubmed-9687855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96878552022-11-25 CircRNAs in Tumor Radioresistance Gao, Yining Gao, Jiawen Lin, Fei Wang, Ting Huo, Sitong Wu, Jiefang Zhou, Qi Zhang, Chao Biomolecules Review Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs’ leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation, regulating host genes, and even being translated into proteins. As some tumor cells are no longer radiosensitive, tumor radioresistance has since become a challenge in treating tumors. In recent years, circRNAs are differentially expressed in tumor cells and can be used as biological markers of tumors. In addition, circRNAs can regulate the radiosensitivity of tumors. Here, we list the mechanisms of circRNAs in glioma, nasopharyngeal carcinoma, and non-small cell lung cancer; further, these studies also provide new ideas for the purposes of eliminating radioresistance in tumors. MDPI 2022-10-28 /pmc/articles/PMC9687855/ /pubmed/36358938 http://dx.doi.org/10.3390/biom12111586 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gao, Yining Gao, Jiawen Lin, Fei Wang, Ting Huo, Sitong Wu, Jiefang Zhou, Qi Zhang, Chao CircRNAs in Tumor Radioresistance |
title | CircRNAs in Tumor Radioresistance |
title_full | CircRNAs in Tumor Radioresistance |
title_fullStr | CircRNAs in Tumor Radioresistance |
title_full_unstemmed | CircRNAs in Tumor Radioresistance |
title_short | CircRNAs in Tumor Radioresistance |
title_sort | circrnas in tumor radioresistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687855/ https://www.ncbi.nlm.nih.gov/pubmed/36358938 http://dx.doi.org/10.3390/biom12111586 |
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