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Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis

The extracellular matrix (ECM) is made up of noncellular components that have special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. osteoglycin (OGN),...

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Autores principales: Nulali, Jiayida, Zhan, Ming, Zhang, Kaiwen, Tu, Pinghui, Liu, Yu, Song, Huaidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687868/
https://www.ncbi.nlm.nih.gov/pubmed/36421687
http://dx.doi.org/10.3390/biom12111674
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author Nulali, Jiayida
Zhan, Ming
Zhang, Kaiwen
Tu, Pinghui
Liu, Yu
Song, Huaidong
author_facet Nulali, Jiayida
Zhan, Ming
Zhang, Kaiwen
Tu, Pinghui
Liu, Yu
Song, Huaidong
author_sort Nulali, Jiayida
collection PubMed
description The extracellular matrix (ECM) is made up of noncellular components that have special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. osteoglycin (OGN), a class III SLRP, is a ubiquitous ECM component that not only helps to organize the extracellular matrix but also regulates a number of important biological processes. As a glycosylated protein in the ECM, OGN was originally considered to be involved in fiber assembly and was reported to have a connection with fibrosis. In addition to these functions, OGN is found in a variety of cancer tissues and is implicated in cellular processes linked to tumorigenesis, including cell proliferation, invasion, metastasis, and epithelial-mesenchymal transition (EMT). In this review, we summarize the structure and functions of OGN as well as its biological and clinical importance in the context of fibrotic illness and tumorigenesis. This review aims to improve our understanding of OGN and provide some new strategies for the treatment of fibrosis and cancer.
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spelling pubmed-96878682022-11-25 Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis Nulali, Jiayida Zhan, Ming Zhang, Kaiwen Tu, Pinghui Liu, Yu Song, Huaidong Biomolecules Review The extracellular matrix (ECM) is made up of noncellular components that have special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. osteoglycin (OGN), a class III SLRP, is a ubiquitous ECM component that not only helps to organize the extracellular matrix but also regulates a number of important biological processes. As a glycosylated protein in the ECM, OGN was originally considered to be involved in fiber assembly and was reported to have a connection with fibrosis. In addition to these functions, OGN is found in a variety of cancer tissues and is implicated in cellular processes linked to tumorigenesis, including cell proliferation, invasion, metastasis, and epithelial-mesenchymal transition (EMT). In this review, we summarize the structure and functions of OGN as well as its biological and clinical importance in the context of fibrotic illness and tumorigenesis. This review aims to improve our understanding of OGN and provide some new strategies for the treatment of fibrosis and cancer. MDPI 2022-11-11 /pmc/articles/PMC9687868/ /pubmed/36421687 http://dx.doi.org/10.3390/biom12111674 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nulali, Jiayida
Zhan, Ming
Zhang, Kaiwen
Tu, Pinghui
Liu, Yu
Song, Huaidong
Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis
title Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis
title_full Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis
title_fullStr Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis
title_full_unstemmed Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis
title_short Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis
title_sort osteoglycin: an ecm factor regulating fibrosis and tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687868/
https://www.ncbi.nlm.nih.gov/pubmed/36421687
http://dx.doi.org/10.3390/biom12111674
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