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Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis
The extracellular matrix (ECM) is made up of noncellular components that have special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. osteoglycin (OGN),...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687868/ https://www.ncbi.nlm.nih.gov/pubmed/36421687 http://dx.doi.org/10.3390/biom12111674 |
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author | Nulali, Jiayida Zhan, Ming Zhang, Kaiwen Tu, Pinghui Liu, Yu Song, Huaidong |
author_facet | Nulali, Jiayida Zhan, Ming Zhang, Kaiwen Tu, Pinghui Liu, Yu Song, Huaidong |
author_sort | Nulali, Jiayida |
collection | PubMed |
description | The extracellular matrix (ECM) is made up of noncellular components that have special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. osteoglycin (OGN), a class III SLRP, is a ubiquitous ECM component that not only helps to organize the extracellular matrix but also regulates a number of important biological processes. As a glycosylated protein in the ECM, OGN was originally considered to be involved in fiber assembly and was reported to have a connection with fibrosis. In addition to these functions, OGN is found in a variety of cancer tissues and is implicated in cellular processes linked to tumorigenesis, including cell proliferation, invasion, metastasis, and epithelial-mesenchymal transition (EMT). In this review, we summarize the structure and functions of OGN as well as its biological and clinical importance in the context of fibrotic illness and tumorigenesis. This review aims to improve our understanding of OGN and provide some new strategies for the treatment of fibrosis and cancer. |
format | Online Article Text |
id | pubmed-9687868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96878682022-11-25 Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis Nulali, Jiayida Zhan, Ming Zhang, Kaiwen Tu, Pinghui Liu, Yu Song, Huaidong Biomolecules Review The extracellular matrix (ECM) is made up of noncellular components that have special properties for influencing cell behavior and tissue structure. Small leucine-rich proteoglycans (SLRPs) are nonfibrillar ECM components that serve as structural scaffolds and signaling molecules. osteoglycin (OGN), a class III SLRP, is a ubiquitous ECM component that not only helps to organize the extracellular matrix but also regulates a number of important biological processes. As a glycosylated protein in the ECM, OGN was originally considered to be involved in fiber assembly and was reported to have a connection with fibrosis. In addition to these functions, OGN is found in a variety of cancer tissues and is implicated in cellular processes linked to tumorigenesis, including cell proliferation, invasion, metastasis, and epithelial-mesenchymal transition (EMT). In this review, we summarize the structure and functions of OGN as well as its biological and clinical importance in the context of fibrotic illness and tumorigenesis. This review aims to improve our understanding of OGN and provide some new strategies for the treatment of fibrosis and cancer. MDPI 2022-11-11 /pmc/articles/PMC9687868/ /pubmed/36421687 http://dx.doi.org/10.3390/biom12111674 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nulali, Jiayida Zhan, Ming Zhang, Kaiwen Tu, Pinghui Liu, Yu Song, Huaidong Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis |
title | Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis |
title_full | Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis |
title_fullStr | Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis |
title_full_unstemmed | Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis |
title_short | Osteoglycin: An ECM Factor Regulating Fibrosis and Tumorigenesis |
title_sort | osteoglycin: an ecm factor regulating fibrosis and tumorigenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687868/ https://www.ncbi.nlm.nih.gov/pubmed/36421687 http://dx.doi.org/10.3390/biom12111674 |
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