Cargando…
Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex
Cumulative animal and human studies have consistently demonstrated that two major cortical regions in the brain, namely the anterior cingulate cortex (ACC) and insular cortex (IC), play critical roles in pain perception and chronic pain. Neuronal synapses in these cortical regions of adult animals a...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687873/ https://www.ncbi.nlm.nih.gov/pubmed/36359264 http://dx.doi.org/10.3390/biomedicines10112745 |
_version_ | 1784836122616004608 |
---|---|
author | Lee, Jung-Hyun Alex Chen, Qiyu Zhuo, Min |
author_facet | Lee, Jung-Hyun Alex Chen, Qiyu Zhuo, Min |
author_sort | Lee, Jung-Hyun Alex |
collection | PubMed |
description | Cumulative animal and human studies have consistently demonstrated that two major cortical regions in the brain, namely the anterior cingulate cortex (ACC) and insular cortex (IC), play critical roles in pain perception and chronic pain. Neuronal synapses in these cortical regions of adult animals are highly plastic and can undergo long-term potentiation (LTP), a phenomenon that is also reported in brain areas for learning and memory (such as the hippocampus). Genetic and pharmacological studies show that inhibiting such cortical LTP can help to reduce behavioral sensitization caused by injury as well as injury-induced emotional changes. In this review, we will summarize recent progress related to synaptic mechanisms for different forms of cortical LTP and their possible contribution to behavioral pain and emotional changes. |
format | Online Article Text |
id | pubmed-9687873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96878732022-11-25 Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex Lee, Jung-Hyun Alex Chen, Qiyu Zhuo, Min Biomedicines Review Cumulative animal and human studies have consistently demonstrated that two major cortical regions in the brain, namely the anterior cingulate cortex (ACC) and insular cortex (IC), play critical roles in pain perception and chronic pain. Neuronal synapses in these cortical regions of adult animals are highly plastic and can undergo long-term potentiation (LTP), a phenomenon that is also reported in brain areas for learning and memory (such as the hippocampus). Genetic and pharmacological studies show that inhibiting such cortical LTP can help to reduce behavioral sensitization caused by injury as well as injury-induced emotional changes. In this review, we will summarize recent progress related to synaptic mechanisms for different forms of cortical LTP and their possible contribution to behavioral pain and emotional changes. MDPI 2022-10-28 /pmc/articles/PMC9687873/ /pubmed/36359264 http://dx.doi.org/10.3390/biomedicines10112745 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, Jung-Hyun Alex Chen, Qiyu Zhuo, Min Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex |
title | Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex |
title_full | Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex |
title_fullStr | Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex |
title_full_unstemmed | Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex |
title_short | Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex |
title_sort | synaptic plasticity in the pain-related cingulate and insular cortex |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687873/ https://www.ncbi.nlm.nih.gov/pubmed/36359264 http://dx.doi.org/10.3390/biomedicines10112745 |
work_keys_str_mv | AT leejunghyunalex synapticplasticityinthepainrelatedcingulateandinsularcortex AT chenqiyu synapticplasticityinthepainrelatedcingulateandinsularcortex AT zhuomin synapticplasticityinthepainrelatedcingulateandinsularcortex |