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Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex

Cumulative animal and human studies have consistently demonstrated that two major cortical regions in the brain, namely the anterior cingulate cortex (ACC) and insular cortex (IC), play critical roles in pain perception and chronic pain. Neuronal synapses in these cortical regions of adult animals a...

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Autores principales: Lee, Jung-Hyun Alex, Chen, Qiyu, Zhuo, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687873/
https://www.ncbi.nlm.nih.gov/pubmed/36359264
http://dx.doi.org/10.3390/biomedicines10112745
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author Lee, Jung-Hyun Alex
Chen, Qiyu
Zhuo, Min
author_facet Lee, Jung-Hyun Alex
Chen, Qiyu
Zhuo, Min
author_sort Lee, Jung-Hyun Alex
collection PubMed
description Cumulative animal and human studies have consistently demonstrated that two major cortical regions in the brain, namely the anterior cingulate cortex (ACC) and insular cortex (IC), play critical roles in pain perception and chronic pain. Neuronal synapses in these cortical regions of adult animals are highly plastic and can undergo long-term potentiation (LTP), a phenomenon that is also reported in brain areas for learning and memory (such as the hippocampus). Genetic and pharmacological studies show that inhibiting such cortical LTP can help to reduce behavioral sensitization caused by injury as well as injury-induced emotional changes. In this review, we will summarize recent progress related to synaptic mechanisms for different forms of cortical LTP and their possible contribution to behavioral pain and emotional changes.
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spelling pubmed-96878732022-11-25 Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex Lee, Jung-Hyun Alex Chen, Qiyu Zhuo, Min Biomedicines Review Cumulative animal and human studies have consistently demonstrated that two major cortical regions in the brain, namely the anterior cingulate cortex (ACC) and insular cortex (IC), play critical roles in pain perception and chronic pain. Neuronal synapses in these cortical regions of adult animals are highly plastic and can undergo long-term potentiation (LTP), a phenomenon that is also reported in brain areas for learning and memory (such as the hippocampus). Genetic and pharmacological studies show that inhibiting such cortical LTP can help to reduce behavioral sensitization caused by injury as well as injury-induced emotional changes. In this review, we will summarize recent progress related to synaptic mechanisms for different forms of cortical LTP and their possible contribution to behavioral pain and emotional changes. MDPI 2022-10-28 /pmc/articles/PMC9687873/ /pubmed/36359264 http://dx.doi.org/10.3390/biomedicines10112745 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Jung-Hyun Alex
Chen, Qiyu
Zhuo, Min
Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex
title Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex
title_full Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex
title_fullStr Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex
title_full_unstemmed Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex
title_short Synaptic Plasticity in the Pain-Related Cingulate and Insular Cortex
title_sort synaptic plasticity in the pain-related cingulate and insular cortex
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687873/
https://www.ncbi.nlm.nih.gov/pubmed/36359264
http://dx.doi.org/10.3390/biomedicines10112745
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