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Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer

The purpose of this study was to explore the relationship between bladder urothelial cancer (BLCA) and immunity, to screen prognosis-related immune genes (PIGs), and to construct an immune-related prognosis model (IRPM). We processed the relevant data of The Cancer Genome Atlas (TCGA-BLCA) and GSE13...

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Autores principales: Zhang, Jiange, Huang, Caisheng, Yang, Rirong, Wang, Xiang, Fang, Bo, Mi, Junhao, Yuan, Hao, Mo, Zengnan, Sun, Yihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687876/
https://www.ncbi.nlm.nih.gov/pubmed/36421685
http://dx.doi.org/10.3390/biom12111670
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author Zhang, Jiange
Huang, Caisheng
Yang, Rirong
Wang, Xiang
Fang, Bo
Mi, Junhao
Yuan, Hao
Mo, Zengnan
Sun, Yihai
author_facet Zhang, Jiange
Huang, Caisheng
Yang, Rirong
Wang, Xiang
Fang, Bo
Mi, Junhao
Yuan, Hao
Mo, Zengnan
Sun, Yihai
author_sort Zhang, Jiange
collection PubMed
description The purpose of this study was to explore the relationship between bladder urothelial cancer (BLCA) and immunity, to screen prognosis-related immune genes (PIGs), and to construct an immune-related prognosis model (IRPM). We processed the relevant data of The Cancer Genome Atlas (TCGA-BLCA) and GSE13507 using R software and Perl. We divided BLCA into high-immunity and low-immunity subtypes. There were significant differences in the two subtypes. In addition, we identified 13 PIGs of BLCA by jointly analyzing the gene expression data and survival information of GSE13507 and TCGA-BLCA, and constructed IRPM through nine of them. The low-risk group had better survival outcome than the high-risk group. We also constructed a nomogram based on clinicopathological information and risk scores of the patients. Moreover, the prognosis of BLCA patients was significantly impacted by the expression of almost every gene used to calculate the risk score. The result of real-time fluorescence quantitative polymerase chain reaction revealed that all the genes used to calculate the risk score were differentially expressed between BLCA and adjacent normal tissues, except PDGFRA. Our research provided potential targets for the treatment of BLCA and a reference for judging the prognosis of BLCA.
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spelling pubmed-96878762022-11-25 Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer Zhang, Jiange Huang, Caisheng Yang, Rirong Wang, Xiang Fang, Bo Mi, Junhao Yuan, Hao Mo, Zengnan Sun, Yihai Biomolecules Article The purpose of this study was to explore the relationship between bladder urothelial cancer (BLCA) and immunity, to screen prognosis-related immune genes (PIGs), and to construct an immune-related prognosis model (IRPM). We processed the relevant data of The Cancer Genome Atlas (TCGA-BLCA) and GSE13507 using R software and Perl. We divided BLCA into high-immunity and low-immunity subtypes. There were significant differences in the two subtypes. In addition, we identified 13 PIGs of BLCA by jointly analyzing the gene expression data and survival information of GSE13507 and TCGA-BLCA, and constructed IRPM through nine of them. The low-risk group had better survival outcome than the high-risk group. We also constructed a nomogram based on clinicopathological information and risk scores of the patients. Moreover, the prognosis of BLCA patients was significantly impacted by the expression of almost every gene used to calculate the risk score. The result of real-time fluorescence quantitative polymerase chain reaction revealed that all the genes used to calculate the risk score were differentially expressed between BLCA and adjacent normal tissues, except PDGFRA. Our research provided potential targets for the treatment of BLCA and a reference for judging the prognosis of BLCA. MDPI 2022-11-11 /pmc/articles/PMC9687876/ /pubmed/36421685 http://dx.doi.org/10.3390/biom12111670 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Jiange
Huang, Caisheng
Yang, Rirong
Wang, Xiang
Fang, Bo
Mi, Junhao
Yuan, Hao
Mo, Zengnan
Sun, Yihai
Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer
title Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer
title_full Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer
title_fullStr Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer
title_full_unstemmed Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer
title_short Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer
title_sort identification of immune-related subtypes and construction of a novel prognostic model for bladder urothelial cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687876/
https://www.ncbi.nlm.nih.gov/pubmed/36421685
http://dx.doi.org/10.3390/biom12111670
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