Cargando…
Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer
The purpose of this study was to explore the relationship between bladder urothelial cancer (BLCA) and immunity, to screen prognosis-related immune genes (PIGs), and to construct an immune-related prognosis model (IRPM). We processed the relevant data of The Cancer Genome Atlas (TCGA-BLCA) and GSE13...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687876/ https://www.ncbi.nlm.nih.gov/pubmed/36421685 http://dx.doi.org/10.3390/biom12111670 |
_version_ | 1784836123611103232 |
---|---|
author | Zhang, Jiange Huang, Caisheng Yang, Rirong Wang, Xiang Fang, Bo Mi, Junhao Yuan, Hao Mo, Zengnan Sun, Yihai |
author_facet | Zhang, Jiange Huang, Caisheng Yang, Rirong Wang, Xiang Fang, Bo Mi, Junhao Yuan, Hao Mo, Zengnan Sun, Yihai |
author_sort | Zhang, Jiange |
collection | PubMed |
description | The purpose of this study was to explore the relationship between bladder urothelial cancer (BLCA) and immunity, to screen prognosis-related immune genes (PIGs), and to construct an immune-related prognosis model (IRPM). We processed the relevant data of The Cancer Genome Atlas (TCGA-BLCA) and GSE13507 using R software and Perl. We divided BLCA into high-immunity and low-immunity subtypes. There were significant differences in the two subtypes. In addition, we identified 13 PIGs of BLCA by jointly analyzing the gene expression data and survival information of GSE13507 and TCGA-BLCA, and constructed IRPM through nine of them. The low-risk group had better survival outcome than the high-risk group. We also constructed a nomogram based on clinicopathological information and risk scores of the patients. Moreover, the prognosis of BLCA patients was significantly impacted by the expression of almost every gene used to calculate the risk score. The result of real-time fluorescence quantitative polymerase chain reaction revealed that all the genes used to calculate the risk score were differentially expressed between BLCA and adjacent normal tissues, except PDGFRA. Our research provided potential targets for the treatment of BLCA and a reference for judging the prognosis of BLCA. |
format | Online Article Text |
id | pubmed-9687876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96878762022-11-25 Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer Zhang, Jiange Huang, Caisheng Yang, Rirong Wang, Xiang Fang, Bo Mi, Junhao Yuan, Hao Mo, Zengnan Sun, Yihai Biomolecules Article The purpose of this study was to explore the relationship between bladder urothelial cancer (BLCA) and immunity, to screen prognosis-related immune genes (PIGs), and to construct an immune-related prognosis model (IRPM). We processed the relevant data of The Cancer Genome Atlas (TCGA-BLCA) and GSE13507 using R software and Perl. We divided BLCA into high-immunity and low-immunity subtypes. There were significant differences in the two subtypes. In addition, we identified 13 PIGs of BLCA by jointly analyzing the gene expression data and survival information of GSE13507 and TCGA-BLCA, and constructed IRPM through nine of them. The low-risk group had better survival outcome than the high-risk group. We also constructed a nomogram based on clinicopathological information and risk scores of the patients. Moreover, the prognosis of BLCA patients was significantly impacted by the expression of almost every gene used to calculate the risk score. The result of real-time fluorescence quantitative polymerase chain reaction revealed that all the genes used to calculate the risk score were differentially expressed between BLCA and adjacent normal tissues, except PDGFRA. Our research provided potential targets for the treatment of BLCA and a reference for judging the prognosis of BLCA. MDPI 2022-11-11 /pmc/articles/PMC9687876/ /pubmed/36421685 http://dx.doi.org/10.3390/biom12111670 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Jiange Huang, Caisheng Yang, Rirong Wang, Xiang Fang, Bo Mi, Junhao Yuan, Hao Mo, Zengnan Sun, Yihai Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer |
title | Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer |
title_full | Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer |
title_fullStr | Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer |
title_full_unstemmed | Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer |
title_short | Identification of Immune-Related Subtypes and Construction of a Novel Prognostic Model for Bladder Urothelial Cancer |
title_sort | identification of immune-related subtypes and construction of a novel prognostic model for bladder urothelial cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687876/ https://www.ncbi.nlm.nih.gov/pubmed/36421685 http://dx.doi.org/10.3390/biom12111670 |
work_keys_str_mv | AT zhangjiange identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer AT huangcaisheng identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer AT yangrirong identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer AT wangxiang identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer AT fangbo identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer AT mijunhao identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer AT yuanhao identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer AT mozengnan identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer AT sunyihai identificationofimmunerelatedsubtypesandconstructionofanovelprognosticmodelforbladderurothelialcancer |