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Lessons Learned from Two Decades of Modeling the Heat-Shock Response
The Heat Shock Response (HSR) is a highly conserved genetic system charged with protecting the proteome in a wide range of organisms and species. Experiments since the early 1980s have elucidated key elements in these pathways and revealed a canonical mode of regulation, which relies on a titration...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687914/ https://www.ncbi.nlm.nih.gov/pubmed/36358995 http://dx.doi.org/10.3390/biom12111645 |
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author | Ranawade, Ayush Sharma, Rati Levine, Erel |
author_facet | Ranawade, Ayush Sharma, Rati Levine, Erel |
author_sort | Ranawade, Ayush |
collection | PubMed |
description | The Heat Shock Response (HSR) is a highly conserved genetic system charged with protecting the proteome in a wide range of organisms and species. Experiments since the early 1980s have elucidated key elements in these pathways and revealed a canonical mode of regulation, which relies on a titration feedback. This system has been subject to substantial modeling work, addressing questions about resilience, design and control. The compact core regulatory circuit, as well as its apparent conservation, make this system an ideal ‘hydrogen atom’ model for the regulation of stress response. Here we take a broad view of the models of the HSR, focusing on the different questions asked and the approaches taken. After 20 years of modeling work, we ask what lessons had been learned that would have been hard to discover without mathematical models. We find that while existing models lay strong foundations, many important questions that can benefit from quantitative modeling are still awaiting investigation. |
format | Online Article Text |
id | pubmed-9687914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96879142022-11-25 Lessons Learned from Two Decades of Modeling the Heat-Shock Response Ranawade, Ayush Sharma, Rati Levine, Erel Biomolecules Review The Heat Shock Response (HSR) is a highly conserved genetic system charged with protecting the proteome in a wide range of organisms and species. Experiments since the early 1980s have elucidated key elements in these pathways and revealed a canonical mode of regulation, which relies on a titration feedback. This system has been subject to substantial modeling work, addressing questions about resilience, design and control. The compact core regulatory circuit, as well as its apparent conservation, make this system an ideal ‘hydrogen atom’ model for the regulation of stress response. Here we take a broad view of the models of the HSR, focusing on the different questions asked and the approaches taken. After 20 years of modeling work, we ask what lessons had been learned that would have been hard to discover without mathematical models. We find that while existing models lay strong foundations, many important questions that can benefit from quantitative modeling are still awaiting investigation. MDPI 2022-11-07 /pmc/articles/PMC9687914/ /pubmed/36358995 http://dx.doi.org/10.3390/biom12111645 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ranawade, Ayush Sharma, Rati Levine, Erel Lessons Learned from Two Decades of Modeling the Heat-Shock Response |
title | Lessons Learned from Two Decades of Modeling the Heat-Shock Response |
title_full | Lessons Learned from Two Decades of Modeling the Heat-Shock Response |
title_fullStr | Lessons Learned from Two Decades of Modeling the Heat-Shock Response |
title_full_unstemmed | Lessons Learned from Two Decades of Modeling the Heat-Shock Response |
title_short | Lessons Learned from Two Decades of Modeling the Heat-Shock Response |
title_sort | lessons learned from two decades of modeling the heat-shock response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687914/ https://www.ncbi.nlm.nih.gov/pubmed/36358995 http://dx.doi.org/10.3390/biom12111645 |
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