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Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient’s COVID-19 Infection

Multiple sclerosis (MS) and its various comorbidities that may be observed are of great interest due to the complexity of MS pathophysiology and all of the immunological changes that follow. The incidence of cancer in MS has been investigated for several years, as not only does it affect ongoing the...

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Autores principales: Markoglou, Nikolaos, Simeakis, George, Alevizaki, Maria, Velonakis, Georgios, Chatzistamatiou, Theofanis, Spyropoulou-Vlachou, Maria, Stavropoulos-Giokas, Catherine, Stefanis, Leonidas, Anagnostouli, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687925/
https://www.ncbi.nlm.nih.gov/pubmed/36359367
http://dx.doi.org/10.3390/biomedicines10112850
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author Markoglou, Nikolaos
Simeakis, George
Alevizaki, Maria
Velonakis, Georgios
Chatzistamatiou, Theofanis
Spyropoulou-Vlachou, Maria
Stavropoulos-Giokas, Catherine
Stefanis, Leonidas
Anagnostouli, Maria
author_facet Markoglou, Nikolaos
Simeakis, George
Alevizaki, Maria
Velonakis, Georgios
Chatzistamatiou, Theofanis
Spyropoulou-Vlachou, Maria
Stavropoulos-Giokas, Catherine
Stefanis, Leonidas
Anagnostouli, Maria
author_sort Markoglou, Nikolaos
collection PubMed
description Multiple sclerosis (MS) and its various comorbidities that may be observed are of great interest due to the complexity of MS pathophysiology and all of the immunological changes that follow. The incidence of cancer in MS has been investigated for several years, as not only does it affect ongoing therapeutical decisions, but also, certain disease-modifying treatments (DMTs) may increase the risk of tumorigenesis. For the first time, we present a case of a female patient with pediatric-onset MS (POMS) and multiple endocrine neoplasia 2B (MEN2B) and analyze the immunological impact of these diseases on the therapeutical choice, under the umbrella of her COVID-19 infection and the SARS-CoV-2 pandemic as a whole. We also review the existing literature regarding the immunogenetic and immunological correlations between these two extremely rare diseases and discuss the most suitable treatment for our case, which seems to be an anti-CD20 agent due to a better outcome in putative MS worsening and tumor progression, when killer immunoglobulin-like receptors’ (KIR) expression is reduced in natural killer (NK) cells. We also broaden our concerns on this comorbidity issue, at the same time focusing on the future research needed in this unexplored field of the comorbidity of MS and cancers.
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spelling pubmed-96879252022-11-25 Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient’s COVID-19 Infection Markoglou, Nikolaos Simeakis, George Alevizaki, Maria Velonakis, Georgios Chatzistamatiou, Theofanis Spyropoulou-Vlachou, Maria Stavropoulos-Giokas, Catherine Stefanis, Leonidas Anagnostouli, Maria Biomedicines Case Report Multiple sclerosis (MS) and its various comorbidities that may be observed are of great interest due to the complexity of MS pathophysiology and all of the immunological changes that follow. The incidence of cancer in MS has been investigated for several years, as not only does it affect ongoing therapeutical decisions, but also, certain disease-modifying treatments (DMTs) may increase the risk of tumorigenesis. For the first time, we present a case of a female patient with pediatric-onset MS (POMS) and multiple endocrine neoplasia 2B (MEN2B) and analyze the immunological impact of these diseases on the therapeutical choice, under the umbrella of her COVID-19 infection and the SARS-CoV-2 pandemic as a whole. We also review the existing literature regarding the immunogenetic and immunological correlations between these two extremely rare diseases and discuss the most suitable treatment for our case, which seems to be an anti-CD20 agent due to a better outcome in putative MS worsening and tumor progression, when killer immunoglobulin-like receptors’ (KIR) expression is reduced in natural killer (NK) cells. We also broaden our concerns on this comorbidity issue, at the same time focusing on the future research needed in this unexplored field of the comorbidity of MS and cancers. MDPI 2022-11-08 /pmc/articles/PMC9687925/ /pubmed/36359367 http://dx.doi.org/10.3390/biomedicines10112850 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Markoglou, Nikolaos
Simeakis, George
Alevizaki, Maria
Velonakis, Georgios
Chatzistamatiou, Theofanis
Spyropoulou-Vlachou, Maria
Stavropoulos-Giokas, Catherine
Stefanis, Leonidas
Anagnostouli, Maria
Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient’s COVID-19 Infection
title Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient’s COVID-19 Infection
title_full Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient’s COVID-19 Infection
title_fullStr Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient’s COVID-19 Infection
title_full_unstemmed Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient’s COVID-19 Infection
title_short Multiple Sclerosis and MEN2 Neoplasia in a Female Patient: A Unique Co-Existence with Expanded Immunological Interest and Therapeutical Challenges, before and after Patient’s COVID-19 Infection
title_sort multiple sclerosis and men2 neoplasia in a female patient: a unique co-existence with expanded immunological interest and therapeutical challenges, before and after patient’s covid-19 infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687925/
https://www.ncbi.nlm.nih.gov/pubmed/36359367
http://dx.doi.org/10.3390/biomedicines10112850
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