Cargando…

Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury

Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur dur...

Descripción completa

Detalles Bibliográficos
Autores principales: Zheng, Yu, Xu, Xinda, Chi, Fanglu, Cong, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687982/
https://www.ncbi.nlm.nih.gov/pubmed/36358975
http://dx.doi.org/10.3390/biom12111625
_version_ 1784836150946430976
author Zheng, Yu
Xu, Xinda
Chi, Fanglu
Cong, Ning
author_facet Zheng, Yu
Xu, Xinda
Chi, Fanglu
Cong, Ning
author_sort Zheng, Yu
collection PubMed
description Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur during I/R injury. Pyroptosis, which is characterized by cell membrane pore formation, pro-inflammatory cytokine release, and cell burst, and which differentiates itself from apoptosis and necroptosis, has been found to be closely related to I/R injury. Therefore, targeting the signaling pathways and key regulators of pyroptosis may be favorable for the treatment of I/R injury, which is far from adequate at present. This review summarizes the current status of pyroptosis and its connection to I/R in different organs, as well as potential treatment strategies targeting it to combat I/R injury.
format Online
Article
Text
id pubmed-9687982
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96879822022-11-25 Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury Zheng, Yu Xu, Xinda Chi, Fanglu Cong, Ning Biomolecules Review Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction. Previous studies have shown that different types of cell death, including apoptosis, necrosis, and autophagy, can occur during I/R injury. Pyroptosis, which is characterized by cell membrane pore formation, pro-inflammatory cytokine release, and cell burst, and which differentiates itself from apoptosis and necroptosis, has been found to be closely related to I/R injury. Therefore, targeting the signaling pathways and key regulators of pyroptosis may be favorable for the treatment of I/R injury, which is far from adequate at present. This review summarizes the current status of pyroptosis and its connection to I/R in different organs, as well as potential treatment strategies targeting it to combat I/R injury. MDPI 2022-11-03 /pmc/articles/PMC9687982/ /pubmed/36358975 http://dx.doi.org/10.3390/biom12111625 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zheng, Yu
Xu, Xinda
Chi, Fanglu
Cong, Ning
Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
title Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
title_full Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
title_fullStr Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
title_full_unstemmed Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
title_short Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
title_sort pyroptosis: a newly discovered therapeutic target for ischemia-reperfusion injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687982/
https://www.ncbi.nlm.nih.gov/pubmed/36358975
http://dx.doi.org/10.3390/biom12111625
work_keys_str_mv AT zhengyu pyroptosisanewlydiscoveredtherapeutictargetforischemiareperfusioninjury
AT xuxinda pyroptosisanewlydiscoveredtherapeutictargetforischemiareperfusioninjury
AT chifanglu pyroptosisanewlydiscoveredtherapeutictargetforischemiareperfusioninjury
AT congning pyroptosisanewlydiscoveredtherapeutictargetforischemiareperfusioninjury