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A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside

Atopic dermatitis (AD) is a common chronic inflammatory and immune-mediated skin disease with a complex pathophysiology and still represents a therapeutic challenge, owing to limited responses to available treatments. However, recent advances in the understanding of AD pathophysiology have led to th...

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Autores principales: Radi, Giulia, Campanti, Anna, Diotallevi, Federico, Martina, Emanuela, Marani, Andrea, Offidani, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688004/
https://www.ncbi.nlm.nih.gov/pubmed/36359220
http://dx.doi.org/10.3390/biomedicines10112700
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author Radi, Giulia
Campanti, Anna
Diotallevi, Federico
Martina, Emanuela
Marani, Andrea
Offidani, Annamaria
author_facet Radi, Giulia
Campanti, Anna
Diotallevi, Federico
Martina, Emanuela
Marani, Andrea
Offidani, Annamaria
author_sort Radi, Giulia
collection PubMed
description Atopic dermatitis (AD) is a common chronic inflammatory and immune-mediated skin disease with a complex pathophysiology and still represents a therapeutic challenge, owing to limited responses to available treatments. However, recent advances in the understanding of AD pathophysiology have led to the discovery of several new potential therapeutic targets, and research in the field of new molecules with therapeutic perspectives is boiling, with more than 70 new promising drugs in development. The aim of this systematic review is to provide the state of the art on the current knowledge concerning the pathophysiology of the disease and on novel agents currently being investigated for AD, and to highlight which type of evolution is going to take place in therapeutic approaches of atopic dermatitis in the coming years.
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spelling pubmed-96880042022-11-25 A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside Radi, Giulia Campanti, Anna Diotallevi, Federico Martina, Emanuela Marani, Andrea Offidani, Annamaria Biomedicines Systematic Review Atopic dermatitis (AD) is a common chronic inflammatory and immune-mediated skin disease with a complex pathophysiology and still represents a therapeutic challenge, owing to limited responses to available treatments. However, recent advances in the understanding of AD pathophysiology have led to the discovery of several new potential therapeutic targets, and research in the field of new molecules with therapeutic perspectives is boiling, with more than 70 new promising drugs in development. The aim of this systematic review is to provide the state of the art on the current knowledge concerning the pathophysiology of the disease and on novel agents currently being investigated for AD, and to highlight which type of evolution is going to take place in therapeutic approaches of atopic dermatitis in the coming years. MDPI 2022-10-25 /pmc/articles/PMC9688004/ /pubmed/36359220 http://dx.doi.org/10.3390/biomedicines10112700 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Radi, Giulia
Campanti, Anna
Diotallevi, Federico
Martina, Emanuela
Marani, Andrea
Offidani, Annamaria
A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside
title A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside
title_full A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside
title_fullStr A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside
title_full_unstemmed A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside
title_short A Systematic Review of Atopic Dermatitis: The Intriguing Journey Starting from Physiopathology to Treatment, from Laboratory Bench to Bedside
title_sort systematic review of atopic dermatitis: the intriguing journey starting from physiopathology to treatment, from laboratory bench to bedside
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688004/
https://www.ncbi.nlm.nih.gov/pubmed/36359220
http://dx.doi.org/10.3390/biomedicines10112700
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