The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis

Ferroptosis is a new type of cell death caused by iron-dependent lipid peroxidation. In recent years, it has been found that ferroptosis can promote the progression of atherosclerosis (AS). Macrophages have been proven to play multiple roles in the occurrence and development of AS. Iron is a necessa...

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Detalles Bibliográficos
Autores principales: Ma, Jiedong, Zhang, Hongqi, Chen, Yufei, Liu, Xiaojin, Tian, Jiamin, Shen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688033/
https://www.ncbi.nlm.nih.gov/pubmed/36421722
http://dx.doi.org/10.3390/biom12111702
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author Ma, Jiedong
Zhang, Hongqi
Chen, Yufei
Liu, Xiaojin
Tian, Jiamin
Shen, Wei
author_facet Ma, Jiedong
Zhang, Hongqi
Chen, Yufei
Liu, Xiaojin
Tian, Jiamin
Shen, Wei
author_sort Ma, Jiedong
collection PubMed
description Ferroptosis is a new type of cell death caused by iron-dependent lipid peroxidation. In recent years, it has been found that ferroptosis can promote the progression of atherosclerosis (AS). Macrophages have been proven to play multiple roles in the occurrence and development of AS. Iron is a necessary mineral that participates in different functions of macrophages under physiological conditions. But iron overload and ferroptosis in macrophages may promote the progression of AS. Herein, we summarize the role of iron overload and ferroptosis in macrophages in AS from the perspective of iron metabolism, and iron overload and ferroptosis are significant contributors to AS development.
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spelling pubmed-96880332022-11-25 The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis Ma, Jiedong Zhang, Hongqi Chen, Yufei Liu, Xiaojin Tian, Jiamin Shen, Wei Biomolecules Review Ferroptosis is a new type of cell death caused by iron-dependent lipid peroxidation. In recent years, it has been found that ferroptosis can promote the progression of atherosclerosis (AS). Macrophages have been proven to play multiple roles in the occurrence and development of AS. Iron is a necessary mineral that participates in different functions of macrophages under physiological conditions. But iron overload and ferroptosis in macrophages may promote the progression of AS. Herein, we summarize the role of iron overload and ferroptosis in macrophages in AS from the perspective of iron metabolism, and iron overload and ferroptosis are significant contributors to AS development. MDPI 2022-11-18 /pmc/articles/PMC9688033/ /pubmed/36421722 http://dx.doi.org/10.3390/biom12111702 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ma, Jiedong
Zhang, Hongqi
Chen, Yufei
Liu, Xiaojin
Tian, Jiamin
Shen, Wei
The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
title The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
title_full The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
title_fullStr The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
title_full_unstemmed The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
title_short The Role of Macrophage Iron Overload and Ferroptosis in Atherosclerosis
title_sort role of macrophage iron overload and ferroptosis in atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688033/
https://www.ncbi.nlm.nih.gov/pubmed/36421722
http://dx.doi.org/10.3390/biom12111702
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