Cargando…

Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with a high degree of immune tolerance. Galectins induce induction of immune evasion behavior in tumor cells. Galectins each play a role in promoting PDAC progression during PDAC immune evasion by coordinating...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Zhengting, Zhang, Wenjie, Sha, Gengyu, Wang, Daorong, Tang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688059/
https://www.ncbi.nlm.nih.gov/pubmed/36428567
http://dx.doi.org/10.3390/cancers14225475
_version_ 1784836171016175616
author Jiang, Zhengting
Zhang, Wenjie
Sha, Gengyu
Wang, Daorong
Tang, Dong
author_facet Jiang, Zhengting
Zhang, Wenjie
Sha, Gengyu
Wang, Daorong
Tang, Dong
author_sort Jiang, Zhengting
collection PubMed
description SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with a high degree of immune tolerance. Galectins induce induction of immune evasion behavior in tumor cells. Galectins each play a role in promoting PDAC progression during PDAC immune evasion by coordinating the function and number of immune cells, especially galectin-1. In this paper. we review the involvement of galectins in the construction of PDAC privileged zones by regulating relevant immune cells, establishing fibrotic barriers, and promoting cellular metabolism. ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and is highly immune tolerant. Although there is immune cell infiltration in PDAC tissues, most of the immune cells do not function properly and, therefore, the prognosis of PDAC is very poor. Galectins are carbohydrate-binding proteins that are intimately involved in the proliferation and metastasis of tumor cells and, in particular, play a crucial role in the immune evasion of tumor cells. Galectins induce abnormal functions and reduce numbers of tumor-associated macrophages (TAM), natural killer cells (NK), T cells and B cells. It further promotes fibrosis of tissues surrounding PDAC, enhances local cellular metabolism, and ultimately constructs tumor immune privileged areas to induce immune evasion behavior of tumor cells. Here, we summarize the respective mechanisms of action played by different Galectins in the process of immune escape from PDAC, focusing on the mechanism of action of Galectin-1. Galectins cause imbalance between tumor immunity and anti-tumor immunity by coordinating the function and number of immune cells, which leads to the development and progression of PDAC.
format Online
Article
Text
id pubmed-9688059
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96880592022-11-25 Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma Jiang, Zhengting Zhang, Wenjie Sha, Gengyu Wang, Daorong Tang, Dong Cancers (Basel) Review SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with a high degree of immune tolerance. Galectins induce induction of immune evasion behavior in tumor cells. Galectins each play a role in promoting PDAC progression during PDAC immune evasion by coordinating the function and number of immune cells, especially galectin-1. In this paper. we review the involvement of galectins in the construction of PDAC privileged zones by regulating relevant immune cells, establishing fibrotic barriers, and promoting cellular metabolism. ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and is highly immune tolerant. Although there is immune cell infiltration in PDAC tissues, most of the immune cells do not function properly and, therefore, the prognosis of PDAC is very poor. Galectins are carbohydrate-binding proteins that are intimately involved in the proliferation and metastasis of tumor cells and, in particular, play a crucial role in the immune evasion of tumor cells. Galectins induce abnormal functions and reduce numbers of tumor-associated macrophages (TAM), natural killer cells (NK), T cells and B cells. It further promotes fibrosis of tissues surrounding PDAC, enhances local cellular metabolism, and ultimately constructs tumor immune privileged areas to induce immune evasion behavior of tumor cells. Here, we summarize the respective mechanisms of action played by different Galectins in the process of immune escape from PDAC, focusing on the mechanism of action of Galectin-1. Galectins cause imbalance between tumor immunity and anti-tumor immunity by coordinating the function and number of immune cells, which leads to the development and progression of PDAC. MDPI 2022-11-08 /pmc/articles/PMC9688059/ /pubmed/36428567 http://dx.doi.org/10.3390/cancers14225475 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jiang, Zhengting
Zhang, Wenjie
Sha, Gengyu
Wang, Daorong
Tang, Dong
Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma
title Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma
title_full Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma
title_fullStr Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma
title_full_unstemmed Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma
title_short Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma
title_sort galectins are central mediators of immune escape in pancreatic ductal adenocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688059/
https://www.ncbi.nlm.nih.gov/pubmed/36428567
http://dx.doi.org/10.3390/cancers14225475
work_keys_str_mv AT jiangzhengting galectinsarecentralmediatorsofimmuneescapeinpancreaticductaladenocarcinoma
AT zhangwenjie galectinsarecentralmediatorsofimmuneescapeinpancreaticductaladenocarcinoma
AT shagengyu galectinsarecentralmediatorsofimmuneescapeinpancreaticductaladenocarcinoma
AT wangdaorong galectinsarecentralmediatorsofimmuneescapeinpancreaticductaladenocarcinoma
AT tangdong galectinsarecentralmediatorsofimmuneescapeinpancreaticductaladenocarcinoma