Cargando…

The Role of Astrocytes in the Mechanism of Perioperative Neurocognitive Disorders

Recently, astrocytes are fast climbing the ladder of importance in cognitive-related diseases. Perioperative neurocognitive disorder (PND) is a common consequence of anesthesia and surgery, which is widely investigated in elderly and susceptible individuals. There is no doubt that astrocytes also pl...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Ying, Lin, Xiaowan, Liu, Xiao, Yu, Kang, Miao, Huihui, Li, Tianzuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688103/
https://www.ncbi.nlm.nih.gov/pubmed/36358362
http://dx.doi.org/10.3390/brainsci12111435
_version_ 1784836182192947200
author Cao, Ying
Lin, Xiaowan
Liu, Xiao
Yu, Kang
Miao, Huihui
Li, Tianzuo
author_facet Cao, Ying
Lin, Xiaowan
Liu, Xiao
Yu, Kang
Miao, Huihui
Li, Tianzuo
author_sort Cao, Ying
collection PubMed
description Recently, astrocytes are fast climbing the ladder of importance in cognitive-related diseases. Perioperative neurocognitive disorder (PND) is a common consequence of anesthesia and surgery, which is widely investigated in elderly and susceptible individuals. There is no doubt that astrocytes also play an irreplaceable role in the pathogenesis of PND. Reactive astrocytes can be found in the PND model, with an altered phenotype and morphology, suggesting a role in the development of the diseases. As a prominent participant cell in the central inflammatory response, the inflammatory response is unavoidably a crucial pathway in the development of the disease. Astrocytes also play a significant role in the homeostasis of the internal environment, neuronal metabolism, and synaptic homeostasis, all of which have an impact on cognitive function. In this article, we discuss the function of astrocytes in PND in order to establish a framework for investigating treatments for PND that target astrocytes.
format Online
Article
Text
id pubmed-9688103
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96881032022-11-25 The Role of Astrocytes in the Mechanism of Perioperative Neurocognitive Disorders Cao, Ying Lin, Xiaowan Liu, Xiao Yu, Kang Miao, Huihui Li, Tianzuo Brain Sci Opinion Recently, astrocytes are fast climbing the ladder of importance in cognitive-related diseases. Perioperative neurocognitive disorder (PND) is a common consequence of anesthesia and surgery, which is widely investigated in elderly and susceptible individuals. There is no doubt that astrocytes also play an irreplaceable role in the pathogenesis of PND. Reactive astrocytes can be found in the PND model, with an altered phenotype and morphology, suggesting a role in the development of the diseases. As a prominent participant cell in the central inflammatory response, the inflammatory response is unavoidably a crucial pathway in the development of the disease. Astrocytes also play a significant role in the homeostasis of the internal environment, neuronal metabolism, and synaptic homeostasis, all of which have an impact on cognitive function. In this article, we discuss the function of astrocytes in PND in order to establish a framework for investigating treatments for PND that target astrocytes. MDPI 2022-10-25 /pmc/articles/PMC9688103/ /pubmed/36358362 http://dx.doi.org/10.3390/brainsci12111435 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Cao, Ying
Lin, Xiaowan
Liu, Xiao
Yu, Kang
Miao, Huihui
Li, Tianzuo
The Role of Astrocytes in the Mechanism of Perioperative Neurocognitive Disorders
title The Role of Astrocytes in the Mechanism of Perioperative Neurocognitive Disorders
title_full The Role of Astrocytes in the Mechanism of Perioperative Neurocognitive Disorders
title_fullStr The Role of Astrocytes in the Mechanism of Perioperative Neurocognitive Disorders
title_full_unstemmed The Role of Astrocytes in the Mechanism of Perioperative Neurocognitive Disorders
title_short The Role of Astrocytes in the Mechanism of Perioperative Neurocognitive Disorders
title_sort role of astrocytes in the mechanism of perioperative neurocognitive disorders
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688103/
https://www.ncbi.nlm.nih.gov/pubmed/36358362
http://dx.doi.org/10.3390/brainsci12111435
work_keys_str_mv AT caoying theroleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT linxiaowan theroleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT liuxiao theroleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT yukang theroleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT miaohuihui theroleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT litianzuo theroleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT caoying roleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT linxiaowan roleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT liuxiao roleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT yukang roleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT miaohuihui roleofastrocytesinthemechanismofperioperativeneurocognitivedisorders
AT litianzuo roleofastrocytesinthemechanismofperioperativeneurocognitivedisorders