Anti-NF155/NF186 IgG4 Antibody Positive Autoimmune Nodopathy

Patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) seropositive for autoantibodies against nodal and paranodal proteins display distinct clinical presentations. In the latest study, CIDP with autoantibodies against paranodal proteins was defined as autoimmune nodopathy (A...

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Autores principales: Wang, Lijun, Pan, Jing, Meng, Huanyu, Yang, Zhao, Zeng, Lili, Liu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688218/
https://www.ncbi.nlm.nih.gov/pubmed/36421911
http://dx.doi.org/10.3390/brainsci12111587
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author Wang, Lijun
Pan, Jing
Meng, Huanyu
Yang, Zhao
Zeng, Lili
Liu, Jun
author_facet Wang, Lijun
Pan, Jing
Meng, Huanyu
Yang, Zhao
Zeng, Lili
Liu, Jun
author_sort Wang, Lijun
collection PubMed
description Patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) seropositive for autoantibodies against nodal and paranodal proteins display distinct clinical presentations. In the latest study, CIDP with autoantibodies against paranodal proteins was defined as autoimmune nodopathy (AN). We herein present a case of 39-year-old male with anti- neurofascin (NF) 155 and NF186 IgG4 antibody with gait disturbance and tremor, who was followed up for 4 months and demonstrated clinical improvements after apparently effective rituximab therapy. In addition, a literature review was conducted to investigate the clinical characteristics of anti-NF155/NF186-positive AN.
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spelling pubmed-96882182022-11-25 Anti-NF155/NF186 IgG4 Antibody Positive Autoimmune Nodopathy Wang, Lijun Pan, Jing Meng, Huanyu Yang, Zhao Zeng, Lili Liu, Jun Brain Sci Case Report Patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) seropositive for autoantibodies against nodal and paranodal proteins display distinct clinical presentations. In the latest study, CIDP with autoantibodies against paranodal proteins was defined as autoimmune nodopathy (AN). We herein present a case of 39-year-old male with anti- neurofascin (NF) 155 and NF186 IgG4 antibody with gait disturbance and tremor, who was followed up for 4 months and demonstrated clinical improvements after apparently effective rituximab therapy. In addition, a literature review was conducted to investigate the clinical characteristics of anti-NF155/NF186-positive AN. MDPI 2022-11-20 /pmc/articles/PMC9688218/ /pubmed/36421911 http://dx.doi.org/10.3390/brainsci12111587 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Wang, Lijun
Pan, Jing
Meng, Huanyu
Yang, Zhao
Zeng, Lili
Liu, Jun
Anti-NF155/NF186 IgG4 Antibody Positive Autoimmune Nodopathy
title Anti-NF155/NF186 IgG4 Antibody Positive Autoimmune Nodopathy
title_full Anti-NF155/NF186 IgG4 Antibody Positive Autoimmune Nodopathy
title_fullStr Anti-NF155/NF186 IgG4 Antibody Positive Autoimmune Nodopathy
title_full_unstemmed Anti-NF155/NF186 IgG4 Antibody Positive Autoimmune Nodopathy
title_short Anti-NF155/NF186 IgG4 Antibody Positive Autoimmune Nodopathy
title_sort anti-nf155/nf186 igg4 antibody positive autoimmune nodopathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688218/
https://www.ncbi.nlm.nih.gov/pubmed/36421911
http://dx.doi.org/10.3390/brainsci12111587
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