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Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey
SIMPLE SUMMARY: Patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 are an even greater challenge for hematologists. To better clarify their outcome, we describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVI...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688278/ https://www.ncbi.nlm.nih.gov/pubmed/36428621 http://dx.doi.org/10.3390/cancers14225530 |
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author | Cattaneo, Chiara Salmanton-García, Jon Marchesi, Francesco El-Ashwah, Shaimaa Itri, Federico Weinbergerová, Barbora Gomes Da Silva, Maria Dargenio, Michelina Dávila-Valls, Julio Martín-Pérez, Sonia Farina, Francesca Van Doesum, Jaap Valković, Toni Besson, Caroline Poulsen, Christian Bjørn López-García, Alberto Žák, Pavel Schönlein, Martin Piukovics, Klára Jaksic, Ozren Cabirta, Alba Ali, Natasha Sili, Uluhan Fracchiolla, Nicola Dragonetti, Giulia Adžić-Vukičević, Tatjana Marchetti, Monia Machado, Marina Glenthøj, Andreas Finizio, Olimpia Demirkan, Fatih Blennow, Ola Tisi, Maria Chiara Omrani, Ali S. Navrátil, Milan Ráčil, Zdeněk Novák, Jan Magliano, Gabriele Jiménez, Moraima Garcia-Vidal, Carolina Erben, Nurettin Del Principe, Maria Ilaria Buquicchio, Caterina Bergantim, Rui Batinić, Josip Al-Khabori, Murtadha Verga, Luisa Szotkowski, Tomáš Samarkos, Michail Ormazabal-Vélez, Irati Meers, Stef Maertens, Johan Pinczés, László Imre Hoenigl, Martin Drgoňa, Ľuboš Cuccaro, Annarosa Bilgin, Yavuz M. Aujayeb, Avinash Rahimli, Laman Gräfe, Stefanie Sciumè, Mariarita Mladenović, Miloš Çolak, Gökçe Melis Sacchi, Maria Vittoria Nordlander, Anna Berg Venemyr, Caroline Hanáková, Michaela García-Poutón, Nicole Emarah, Ziad Zambrotta, Giovanni Paolo Maria Nunes Rodrigues, Raquel Cordoba, Raul Méndez, Gustavo-Adolfo Biernat, Monika M. Cornely, Oliver A. Pagano, Livio |
author_facet | Cattaneo, Chiara Salmanton-García, Jon Marchesi, Francesco El-Ashwah, Shaimaa Itri, Federico Weinbergerová, Barbora Gomes Da Silva, Maria Dargenio, Michelina Dávila-Valls, Julio Martín-Pérez, Sonia Farina, Francesca Van Doesum, Jaap Valković, Toni Besson, Caroline Poulsen, Christian Bjørn López-García, Alberto Žák, Pavel Schönlein, Martin Piukovics, Klára Jaksic, Ozren Cabirta, Alba Ali, Natasha Sili, Uluhan Fracchiolla, Nicola Dragonetti, Giulia Adžić-Vukičević, Tatjana Marchetti, Monia Machado, Marina Glenthøj, Andreas Finizio, Olimpia Demirkan, Fatih Blennow, Ola Tisi, Maria Chiara Omrani, Ali S. Navrátil, Milan Ráčil, Zdeněk Novák, Jan Magliano, Gabriele Jiménez, Moraima Garcia-Vidal, Carolina Erben, Nurettin Del Principe, Maria Ilaria Buquicchio, Caterina Bergantim, Rui Batinić, Josip Al-Khabori, Murtadha Verga, Luisa Szotkowski, Tomáš Samarkos, Michail Ormazabal-Vélez, Irati Meers, Stef Maertens, Johan Pinczés, László Imre Hoenigl, Martin Drgoňa, Ľuboš Cuccaro, Annarosa Bilgin, Yavuz M. Aujayeb, Avinash Rahimli, Laman Gräfe, Stefanie Sciumè, Mariarita Mladenović, Miloš Çolak, Gökçe Melis Sacchi, Maria Vittoria Nordlander, Anna Berg Venemyr, Caroline Hanáková, Michaela García-Poutón, Nicole Emarah, Ziad Zambrotta, Giovanni Paolo Maria Nunes Rodrigues, Raquel Cordoba, Raul Méndez, Gustavo-Adolfo Biernat, Monika M. Cornely, Oliver A. Pagano, Livio |
author_sort | Cattaneo, Chiara |
collection | PubMed |
description | SIMPLE SUMMARY: Patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 are an even greater challenge for hematologists. To better clarify their outcome, we describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Overall, 343 (76.2%) patients received treatment for HM, and an overall response rate was observed in 140 (40.8%) patients after the first line of treatment. Thirty-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004). Statistical analysis showed that, together with age, severe/critical COVID-19, ≥2 comorbidities, lack of HM treatment was an independent risk factors for mortality. These observations suggest the importance of HM treatment in these patients; therefore, it should be delivered as soon as possible for patients requiring immediate therapy. ABSTRACT: Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (16.6%). An overall response rate was observed in 140 (40.8%) patients after the first line of treatment. After a median follow-up of 35 days, overall mortality was 177/450 (39.3%); 30-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004), either before and/or after COVID-19, or compared to patients receiving HM treatment at least after COVID-19 (15.2%, p < 0.001). Age, severe/critical COVID-19, ≥2 comorbidities, and lack of HM treatment were independent risk factors for mortality, whereas a lymphocyte count >500/mcl at COVID-19 onset was protective. Conclusions: HM treatment should be delivered as soon as possible for patients with simultaneous diagnosis of COVID-19 and HM requiring immediate therapy. |
format | Online Article Text |
id | pubmed-9688278 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96882782022-11-25 Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey Cattaneo, Chiara Salmanton-García, Jon Marchesi, Francesco El-Ashwah, Shaimaa Itri, Federico Weinbergerová, Barbora Gomes Da Silva, Maria Dargenio, Michelina Dávila-Valls, Julio Martín-Pérez, Sonia Farina, Francesca Van Doesum, Jaap Valković, Toni Besson, Caroline Poulsen, Christian Bjørn López-García, Alberto Žák, Pavel Schönlein, Martin Piukovics, Klára Jaksic, Ozren Cabirta, Alba Ali, Natasha Sili, Uluhan Fracchiolla, Nicola Dragonetti, Giulia Adžić-Vukičević, Tatjana Marchetti, Monia Machado, Marina Glenthøj, Andreas Finizio, Olimpia Demirkan, Fatih Blennow, Ola Tisi, Maria Chiara Omrani, Ali S. Navrátil, Milan Ráčil, Zdeněk Novák, Jan Magliano, Gabriele Jiménez, Moraima Garcia-Vidal, Carolina Erben, Nurettin Del Principe, Maria Ilaria Buquicchio, Caterina Bergantim, Rui Batinić, Josip Al-Khabori, Murtadha Verga, Luisa Szotkowski, Tomáš Samarkos, Michail Ormazabal-Vélez, Irati Meers, Stef Maertens, Johan Pinczés, László Imre Hoenigl, Martin Drgoňa, Ľuboš Cuccaro, Annarosa Bilgin, Yavuz M. Aujayeb, Avinash Rahimli, Laman Gräfe, Stefanie Sciumè, Mariarita Mladenović, Miloš Çolak, Gökçe Melis Sacchi, Maria Vittoria Nordlander, Anna Berg Venemyr, Caroline Hanáková, Michaela García-Poutón, Nicole Emarah, Ziad Zambrotta, Giovanni Paolo Maria Nunes Rodrigues, Raquel Cordoba, Raul Méndez, Gustavo-Adolfo Biernat, Monika M. Cornely, Oliver A. Pagano, Livio Cancers (Basel) Article SIMPLE SUMMARY: Patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 are an even greater challenge for hematologists. To better clarify their outcome, we describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Overall, 343 (76.2%) patients received treatment for HM, and an overall response rate was observed in 140 (40.8%) patients after the first line of treatment. Thirty-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004). Statistical analysis showed that, together with age, severe/critical COVID-19, ≥2 comorbidities, lack of HM treatment was an independent risk factors for mortality. These observations suggest the importance of HM treatment in these patients; therefore, it should be delivered as soon as possible for patients requiring immediate therapy. ABSTRACT: Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (16.6%). An overall response rate was observed in 140 (40.8%) patients after the first line of treatment. After a median follow-up of 35 days, overall mortality was 177/450 (39.3%); 30-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004), either before and/or after COVID-19, or compared to patients receiving HM treatment at least after COVID-19 (15.2%, p < 0.001). Age, severe/critical COVID-19, ≥2 comorbidities, and lack of HM treatment were independent risk factors for mortality, whereas a lymphocyte count >500/mcl at COVID-19 onset was protective. Conclusions: HM treatment should be delivered as soon as possible for patients with simultaneous diagnosis of COVID-19 and HM requiring immediate therapy. MDPI 2022-11-10 /pmc/articles/PMC9688278/ /pubmed/36428621 http://dx.doi.org/10.3390/cancers14225530 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cattaneo, Chiara Salmanton-García, Jon Marchesi, Francesco El-Ashwah, Shaimaa Itri, Federico Weinbergerová, Barbora Gomes Da Silva, Maria Dargenio, Michelina Dávila-Valls, Julio Martín-Pérez, Sonia Farina, Francesca Van Doesum, Jaap Valković, Toni Besson, Caroline Poulsen, Christian Bjørn López-García, Alberto Žák, Pavel Schönlein, Martin Piukovics, Klára Jaksic, Ozren Cabirta, Alba Ali, Natasha Sili, Uluhan Fracchiolla, Nicola Dragonetti, Giulia Adžić-Vukičević, Tatjana Marchetti, Monia Machado, Marina Glenthøj, Andreas Finizio, Olimpia Demirkan, Fatih Blennow, Ola Tisi, Maria Chiara Omrani, Ali S. Navrátil, Milan Ráčil, Zdeněk Novák, Jan Magliano, Gabriele Jiménez, Moraima Garcia-Vidal, Carolina Erben, Nurettin Del Principe, Maria Ilaria Buquicchio, Caterina Bergantim, Rui Batinić, Josip Al-Khabori, Murtadha Verga, Luisa Szotkowski, Tomáš Samarkos, Michail Ormazabal-Vélez, Irati Meers, Stef Maertens, Johan Pinczés, László Imre Hoenigl, Martin Drgoňa, Ľuboš Cuccaro, Annarosa Bilgin, Yavuz M. Aujayeb, Avinash Rahimli, Laman Gräfe, Stefanie Sciumè, Mariarita Mladenović, Miloš Çolak, Gökçe Melis Sacchi, Maria Vittoria Nordlander, Anna Berg Venemyr, Caroline Hanáková, Michaela García-Poutón, Nicole Emarah, Ziad Zambrotta, Giovanni Paolo Maria Nunes Rodrigues, Raquel Cordoba, Raul Méndez, Gustavo-Adolfo Biernat, Monika M. Cornely, Oliver A. Pagano, Livio Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey |
title | Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey |
title_full | Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey |
title_fullStr | Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey |
title_full_unstemmed | Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey |
title_short | Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey |
title_sort | simultaneous onset of haematological malignancy and covid: an epicovideha survey |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688278/ https://www.ncbi.nlm.nih.gov/pubmed/36428621 http://dx.doi.org/10.3390/cancers14225530 |
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