Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins

Clostridioides bacteria are responsible for life threatening infections. Here, we show that in addition to actin, the binary toxins CDT, C2I, and Iota from Clostridioides difficile, botulinum, and perfrigens, respectively, ADP-ribosylate the actin-related protein Arp2 of Arp2/3 complex and its addit...

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Detalles Bibliográficos
Autores principales: Schwan, Carsten, Lang, Alexander E., Schlosser, Andreas, Fujita-Becker, Setsuko, AlHaj, Abdulatif, Schröder, Rasmus R., Faix, Jan, Aktories, Klaus, Mannherz, Hans Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688287/
https://www.ncbi.nlm.nih.gov/pubmed/36429089
http://dx.doi.org/10.3390/cells11223661

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