Cargando…
A Concise Review on Dysregulation of LINC00665 in Cancers
Long Intergenic Non-Protein Coding RNA 665 (LINC00665) is an RNA gene located on the minus strand of chromosome 19. This lncRNA acts as a competing endogenous RNA for miR-4458, miR-379-5p, miR-551b-5p, miR-3619-5p, miR-424-5p, miR-9-5p, miR-214-3p, miR-126-5p, miR-149-3p, miR-379-5p, miR-665, miR-34...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688310/ https://www.ncbi.nlm.nih.gov/pubmed/36429005 http://dx.doi.org/10.3390/cells11223575 |
_version_ | 1784836236279545856 |
---|---|
author | Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Baniahmad, Aria Taheri, Mohammad Hajiesmaeili, Mohammadreza |
author_facet | Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Baniahmad, Aria Taheri, Mohammad Hajiesmaeili, Mohammadreza |
author_sort | Ghafouri-Fard, Soudeh |
collection | PubMed |
description | Long Intergenic Non-Protein Coding RNA 665 (LINC00665) is an RNA gene located on the minus strand of chromosome 19. This lncRNA acts as a competing endogenous RNA for miR-4458, miR-379-5p, miR-551b-5p, miR-3619-5p, miR-424-5p, miR-9-5p, miR-214-3p, miR-126-5p, miR-149-3p, miR-379-5p, miR-665, miR-34a-5p, miR-186-5p, miR-138-5p, miR-181c-5p, miR-98, miR-195-5p, miR-224-5p, miR-3619, miR-708, miR-101, miR-1224-5p, miR-34a-5p, and miR-142-5p. Via influencing expression of these miRNAs, it can enhance expression of a number of oncogenes. Moreover, LINC00665 can influence activity of Wnt/β-Catenin, TGF-β, MAPK1, NF-κB, ERK, and PI3K/AKT signaling. Function of this lncRNA has been assessed through gain-of-function tests and/or loss-of-function studies. Furthermore, diverse research groups have evaluated its expression levels in tissue samples using microarray and RT-qPCR techniques. In this manuscript, we have summarized the results of these studies and categorized them in three sections, i.e., cell line studies, animal studies, and investigations in clinical samples. |
format | Online Article Text |
id | pubmed-9688310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96883102022-11-25 A Concise Review on Dysregulation of LINC00665 in Cancers Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Baniahmad, Aria Taheri, Mohammad Hajiesmaeili, Mohammadreza Cells Review Long Intergenic Non-Protein Coding RNA 665 (LINC00665) is an RNA gene located on the minus strand of chromosome 19. This lncRNA acts as a competing endogenous RNA for miR-4458, miR-379-5p, miR-551b-5p, miR-3619-5p, miR-424-5p, miR-9-5p, miR-214-3p, miR-126-5p, miR-149-3p, miR-379-5p, miR-665, miR-34a-5p, miR-186-5p, miR-138-5p, miR-181c-5p, miR-98, miR-195-5p, miR-224-5p, miR-3619, miR-708, miR-101, miR-1224-5p, miR-34a-5p, and miR-142-5p. Via influencing expression of these miRNAs, it can enhance expression of a number of oncogenes. Moreover, LINC00665 can influence activity of Wnt/β-Catenin, TGF-β, MAPK1, NF-κB, ERK, and PI3K/AKT signaling. Function of this lncRNA has been assessed through gain-of-function tests and/or loss-of-function studies. Furthermore, diverse research groups have evaluated its expression levels in tissue samples using microarray and RT-qPCR techniques. In this manuscript, we have summarized the results of these studies and categorized them in three sections, i.e., cell line studies, animal studies, and investigations in clinical samples. MDPI 2022-11-11 /pmc/articles/PMC9688310/ /pubmed/36429005 http://dx.doi.org/10.3390/cells11223575 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Baniahmad, Aria Taheri, Mohammad Hajiesmaeili, Mohammadreza A Concise Review on Dysregulation of LINC00665 in Cancers |
title | A Concise Review on Dysregulation of LINC00665 in Cancers |
title_full | A Concise Review on Dysregulation of LINC00665 in Cancers |
title_fullStr | A Concise Review on Dysregulation of LINC00665 in Cancers |
title_full_unstemmed | A Concise Review on Dysregulation of LINC00665 in Cancers |
title_short | A Concise Review on Dysregulation of LINC00665 in Cancers |
title_sort | concise review on dysregulation of linc00665 in cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688310/ https://www.ncbi.nlm.nih.gov/pubmed/36429005 http://dx.doi.org/10.3390/cells11223575 |
work_keys_str_mv | AT ghafourifardsoudeh aconcisereviewondysregulationoflinc00665incancers AT khoshbakhttayyebeh aconcisereviewondysregulationoflinc00665incancers AT hussenbashdarmahmud aconcisereviewondysregulationoflinc00665incancers AT baniahmadaria aconcisereviewondysregulationoflinc00665incancers AT taherimohammad aconcisereviewondysregulationoflinc00665incancers AT hajiesmaeilimohammadreza aconcisereviewondysregulationoflinc00665incancers AT ghafourifardsoudeh concisereviewondysregulationoflinc00665incancers AT khoshbakhttayyebeh concisereviewondysregulationoflinc00665incancers AT hussenbashdarmahmud concisereviewondysregulationoflinc00665incancers AT baniahmadaria concisereviewondysregulationoflinc00665incancers AT taherimohammad concisereviewondysregulationoflinc00665incancers AT hajiesmaeilimohammadreza concisereviewondysregulationoflinc00665incancers |