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CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages

Tumour heterogeneity refers to the complexity of cell subpopulations coexisting within the tumour microenvironment (TME), such as proliferating tumour cells, tumour stromal cells and infiltrating immune cells. The bidirectional interactions between cancer and the surrounding microenvironment mark th...

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Autores principales: Zaidi, Noorzaileen Eileena, Shazali, Nur Aima Hafiza, Leow, Thean-Chor, Osman, Mohd Azuraidi, Ibrahim, Kamariah, Cheng, Wan-Hee, Lai, Kok-Song, Nik Abd Rahman, Nik Mohd Afizan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688315/
https://www.ncbi.nlm.nih.gov/pubmed/36428985
http://dx.doi.org/10.3390/cells11223556
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author Zaidi, Noorzaileen Eileena
Shazali, Nur Aima Hafiza
Leow, Thean-Chor
Osman, Mohd Azuraidi
Ibrahim, Kamariah
Cheng, Wan-Hee
Lai, Kok-Song
Nik Abd Rahman, Nik Mohd Afizan
author_facet Zaidi, Noorzaileen Eileena
Shazali, Nur Aima Hafiza
Leow, Thean-Chor
Osman, Mohd Azuraidi
Ibrahim, Kamariah
Cheng, Wan-Hee
Lai, Kok-Song
Nik Abd Rahman, Nik Mohd Afizan
author_sort Zaidi, Noorzaileen Eileena
collection PubMed
description Tumour heterogeneity refers to the complexity of cell subpopulations coexisting within the tumour microenvironment (TME), such as proliferating tumour cells, tumour stromal cells and infiltrating immune cells. The bidirectional interactions between cancer and the surrounding microenvironment mark the tumour survival and promotion functions, which allow the cancer cells to become invasive and initiate the metastatic cascade. Importantly, these interactions have been closely associated with metabolic reprogramming, which can modulate the differentiation and functions of immune cells and thus initiate the antitumour response. The purpose of this report is to review the CD36 receptor, a prominent cell receptor in metabolic activity specifically in fatty acid (FA) uptake, for the metabolic symbiosis of cancer–macrophage. In this review, we provide an update on metabolic communication between tumour cells and macrophages, as well as how the immunometabolism indirectly orchestrates the tumour metastasis.
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spelling pubmed-96883152022-11-25 CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages Zaidi, Noorzaileen Eileena Shazali, Nur Aima Hafiza Leow, Thean-Chor Osman, Mohd Azuraidi Ibrahim, Kamariah Cheng, Wan-Hee Lai, Kok-Song Nik Abd Rahman, Nik Mohd Afizan Cells Review Tumour heterogeneity refers to the complexity of cell subpopulations coexisting within the tumour microenvironment (TME), such as proliferating tumour cells, tumour stromal cells and infiltrating immune cells. The bidirectional interactions between cancer and the surrounding microenvironment mark the tumour survival and promotion functions, which allow the cancer cells to become invasive and initiate the metastatic cascade. Importantly, these interactions have been closely associated with metabolic reprogramming, which can modulate the differentiation and functions of immune cells and thus initiate the antitumour response. The purpose of this report is to review the CD36 receptor, a prominent cell receptor in metabolic activity specifically in fatty acid (FA) uptake, for the metabolic symbiosis of cancer–macrophage. In this review, we provide an update on metabolic communication between tumour cells and macrophages, as well as how the immunometabolism indirectly orchestrates the tumour metastasis. MDPI 2022-11-10 /pmc/articles/PMC9688315/ /pubmed/36428985 http://dx.doi.org/10.3390/cells11223556 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zaidi, Noorzaileen Eileena
Shazali, Nur Aima Hafiza
Leow, Thean-Chor
Osman, Mohd Azuraidi
Ibrahim, Kamariah
Cheng, Wan-Hee
Lai, Kok-Song
Nik Abd Rahman, Nik Mohd Afizan
CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
title CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
title_full CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
title_fullStr CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
title_full_unstemmed CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
title_short CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
title_sort cd36-fatty acid-mediated metastasis via the bidirectional interactions of cancer cells and macrophages
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688315/
https://www.ncbi.nlm.nih.gov/pubmed/36428985
http://dx.doi.org/10.3390/cells11223556
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