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Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome
Background and objectives: During the COVID-19 pandemic, we followed with concern the evolution of several children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C). The purpose of this study is to describe the evolution of MIS-C in a previously healthy 3-year-old girl. Methods:...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688372/ https://www.ncbi.nlm.nih.gov/pubmed/36360381 http://dx.doi.org/10.3390/children9111653 |
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author | Santos, Mônica de Oliveira Ribeiro, Diuly Caroline Rocha, Jordanna Sousa Maia, Sibely Braga Santos Moreira, André Luís Elias Silva, Paulo Alex Neves Ito, Célia Regina Malveste Carneiro, Lilian Carla Avelino, Melissa Ameloti Gomes |
author_facet | Santos, Mônica de Oliveira Ribeiro, Diuly Caroline Rocha, Jordanna Sousa Maia, Sibely Braga Santos Moreira, André Luís Elias Silva, Paulo Alex Neves Ito, Célia Regina Malveste Carneiro, Lilian Carla Avelino, Melissa Ameloti Gomes |
author_sort | Santos, Mônica de Oliveira |
collection | PubMed |
description | Background and objectives: During the COVID-19 pandemic, we followed with concern the evolution of several children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C). The purpose of this study is to describe the evolution of MIS-C in a previously healthy 3-year-old girl. Methods: We tracked the daily medical report of all children admitted with suspected MIS-C to the five largest regional hospitals. Results: Our screening identified a child who had several neurological complications associated with MIS-C. We report hematological alterations, transient cardiac dysfunction, and cerebral involvements such as laminar cortical necrosis caused by ischemic stroke. We present the course of treatment and clinical outcome, and other complications such as a severe subglottic stenosis occurring after extubation. Conclusion: Subglottic stenosis is an expected complication after prolonged intubation, and the presence of dysphonia and/or stridor is an important predictive factor. MIS-C with severe neurological alteration may occur in a healthy child, and early diagnosis and treatment with a pulse of corticoid with immunoglobulin are essential for a favorable outcome. |
format | Online Article Text |
id | pubmed-9688372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96883722022-11-25 Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome Santos, Mônica de Oliveira Ribeiro, Diuly Caroline Rocha, Jordanna Sousa Maia, Sibely Braga Santos Moreira, André Luís Elias Silva, Paulo Alex Neves Ito, Célia Regina Malveste Carneiro, Lilian Carla Avelino, Melissa Ameloti Gomes Children (Basel) Case Report Background and objectives: During the COVID-19 pandemic, we followed with concern the evolution of several children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C). The purpose of this study is to describe the evolution of MIS-C in a previously healthy 3-year-old girl. Methods: We tracked the daily medical report of all children admitted with suspected MIS-C to the five largest regional hospitals. Results: Our screening identified a child who had several neurological complications associated with MIS-C. We report hematological alterations, transient cardiac dysfunction, and cerebral involvements such as laminar cortical necrosis caused by ischemic stroke. We present the course of treatment and clinical outcome, and other complications such as a severe subglottic stenosis occurring after extubation. Conclusion: Subglottic stenosis is an expected complication after prolonged intubation, and the presence of dysphonia and/or stridor is an important predictive factor. MIS-C with severe neurological alteration may occur in a healthy child, and early diagnosis and treatment with a pulse of corticoid with immunoglobulin are essential for a favorable outcome. MDPI 2022-10-29 /pmc/articles/PMC9688372/ /pubmed/36360381 http://dx.doi.org/10.3390/children9111653 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Santos, Mônica de Oliveira Ribeiro, Diuly Caroline Rocha, Jordanna Sousa Maia, Sibely Braga Santos Moreira, André Luís Elias Silva, Paulo Alex Neves Ito, Célia Regina Malveste Carneiro, Lilian Carla Avelino, Melissa Ameloti Gomes Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome |
title | Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome |
title_full | Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome |
title_fullStr | Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome |
title_full_unstemmed | Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome |
title_short | Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome |
title_sort | severe neurological manifestation in a child with multisystem inflammatory syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688372/ https://www.ncbi.nlm.nih.gov/pubmed/36360381 http://dx.doi.org/10.3390/children9111653 |
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