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Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome

Background and objectives: During the COVID-19 pandemic, we followed with concern the evolution of several children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C). The purpose of this study is to describe the evolution of MIS-C in a previously healthy 3-year-old girl. Methods:...

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Autores principales: Santos, Mônica de Oliveira, Ribeiro, Diuly Caroline, Rocha, Jordanna Sousa, Maia, Sibely Braga Santos, Moreira, André Luís Elias, Silva, Paulo Alex Neves, Ito, Célia Regina Malveste, Carneiro, Lilian Carla, Avelino, Melissa Ameloti Gomes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688372/
https://www.ncbi.nlm.nih.gov/pubmed/36360381
http://dx.doi.org/10.3390/children9111653
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author Santos, Mônica de Oliveira
Ribeiro, Diuly Caroline
Rocha, Jordanna Sousa
Maia, Sibely Braga Santos
Moreira, André Luís Elias
Silva, Paulo Alex Neves
Ito, Célia Regina Malveste
Carneiro, Lilian Carla
Avelino, Melissa Ameloti Gomes
author_facet Santos, Mônica de Oliveira
Ribeiro, Diuly Caroline
Rocha, Jordanna Sousa
Maia, Sibely Braga Santos
Moreira, André Luís Elias
Silva, Paulo Alex Neves
Ito, Célia Regina Malveste
Carneiro, Lilian Carla
Avelino, Melissa Ameloti Gomes
author_sort Santos, Mônica de Oliveira
collection PubMed
description Background and objectives: During the COVID-19 pandemic, we followed with concern the evolution of several children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C). The purpose of this study is to describe the evolution of MIS-C in a previously healthy 3-year-old girl. Methods: We tracked the daily medical report of all children admitted with suspected MIS-C to the five largest regional hospitals. Results: Our screening identified a child who had several neurological complications associated with MIS-C. We report hematological alterations, transient cardiac dysfunction, and cerebral involvements such as laminar cortical necrosis caused by ischemic stroke. We present the course of treatment and clinical outcome, and other complications such as a severe subglottic stenosis occurring after extubation. Conclusion: Subglottic stenosis is an expected complication after prolonged intubation, and the presence of dysphonia and/or stridor is an important predictive factor. MIS-C with severe neurological alteration may occur in a healthy child, and early diagnosis and treatment with a pulse of corticoid with immunoglobulin are essential for a favorable outcome.
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spelling pubmed-96883722022-11-25 Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome Santos, Mônica de Oliveira Ribeiro, Diuly Caroline Rocha, Jordanna Sousa Maia, Sibely Braga Santos Moreira, André Luís Elias Silva, Paulo Alex Neves Ito, Célia Regina Malveste Carneiro, Lilian Carla Avelino, Melissa Ameloti Gomes Children (Basel) Case Report Background and objectives: During the COVID-19 pandemic, we followed with concern the evolution of several children diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C). The purpose of this study is to describe the evolution of MIS-C in a previously healthy 3-year-old girl. Methods: We tracked the daily medical report of all children admitted with suspected MIS-C to the five largest regional hospitals. Results: Our screening identified a child who had several neurological complications associated with MIS-C. We report hematological alterations, transient cardiac dysfunction, and cerebral involvements such as laminar cortical necrosis caused by ischemic stroke. We present the course of treatment and clinical outcome, and other complications such as a severe subglottic stenosis occurring after extubation. Conclusion: Subglottic stenosis is an expected complication after prolonged intubation, and the presence of dysphonia and/or stridor is an important predictive factor. MIS-C with severe neurological alteration may occur in a healthy child, and early diagnosis and treatment with a pulse of corticoid with immunoglobulin are essential for a favorable outcome. MDPI 2022-10-29 /pmc/articles/PMC9688372/ /pubmed/36360381 http://dx.doi.org/10.3390/children9111653 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Santos, Mônica de Oliveira
Ribeiro, Diuly Caroline
Rocha, Jordanna Sousa
Maia, Sibely Braga Santos
Moreira, André Luís Elias
Silva, Paulo Alex Neves
Ito, Célia Regina Malveste
Carneiro, Lilian Carla
Avelino, Melissa Ameloti Gomes
Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome
title Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome
title_full Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome
title_fullStr Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome
title_full_unstemmed Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome
title_short Severe Neurological Manifestation in a Child with Multisystem Inflammatory Syndrome
title_sort severe neurological manifestation in a child with multisystem inflammatory syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688372/
https://www.ncbi.nlm.nih.gov/pubmed/36360381
http://dx.doi.org/10.3390/children9111653
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