Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats

Oxidative stress and inflammation damage play pivotal roles in vascular dementia (VaD). Trimethylamine N-oxide (TMAO), an intestinal microbiota-stemming metabolite, was reported to promote inflammation and oxidative stress, involved in the etiology of several diseases. Still, these effects have not...

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Detalles Bibliográficos
Autores principales: Deng, Yang, Zou, Junqing, Hong, Ye, Peng, Qiang, Fu, Xinxin, Duan, Rui, Chen, Jie, Chen, Xiangliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688447/
https://www.ncbi.nlm.nih.gov/pubmed/36429082
http://dx.doi.org/10.3390/cells11223650

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