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Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays
Parkinson’s disease (PD) is a neurodegenerative disorder often associated with pre-motor symptoms involving both gastrointestinal and olfactory tissues. PD patients frequently suffer from hyposmia, hyposalivation, dysphagia and gastrointestinal dysfunctions. During the last few years it has been spe...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688507/ https://www.ncbi.nlm.nih.gov/pubmed/36421902 http://dx.doi.org/10.3390/brainsci12111579 |
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author | Consonni, Alessandra Miglietti, Martina De Luca, Chiara Maria Giulia Cazzaniga, Federico Angelo Ciullini, Arianna Dellarole, Ilaria Linda Bufano, Giuseppe Di Fonzo, Alessio Giaccone, Giorgio Baggi, Fulvio Moda, Fabio |
author_facet | Consonni, Alessandra Miglietti, Martina De Luca, Chiara Maria Giulia Cazzaniga, Federico Angelo Ciullini, Arianna Dellarole, Ilaria Linda Bufano, Giuseppe Di Fonzo, Alessio Giaccone, Giorgio Baggi, Fulvio Moda, Fabio |
author_sort | Consonni, Alessandra |
collection | PubMed |
description | Parkinson’s disease (PD) is a neurodegenerative disorder often associated with pre-motor symptoms involving both gastrointestinal and olfactory tissues. PD patients frequently suffer from hyposmia, hyposalivation, dysphagia and gastrointestinal dysfunctions. During the last few years it has been speculated that microbial agents could play a crucial role in PD. In particular, alterations of the microbiota composition (dysbiosis) might contribute to the formation of misfolded α-synuclein, which is believed to be the leading cause of PD. However, while several findings confirmed that there might be an important link between intestinal microbiota alterations and PD onset, little is known about the potential contribution of the nasal microbiota. Here, we describe the latest findings on this topic by considering that more than 80% of patients with PD develop remarkable olfactory deficits in their prodromal disease stage. Therefore, the nasal microbiota might contribute to PD, eventually boosting the gut microbiota in promoting disease onset. Finally, we present the applications of the seed amplification assays to the study of the gut and olfactory mucosa of PD patients, and how they could be exploited to investigate whether pathogenic bacteria present in the gut and the nose might promote α-synuclein misfolding and aggregation. |
format | Online Article Text |
id | pubmed-9688507 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96885072022-11-25 Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays Consonni, Alessandra Miglietti, Martina De Luca, Chiara Maria Giulia Cazzaniga, Federico Angelo Ciullini, Arianna Dellarole, Ilaria Linda Bufano, Giuseppe Di Fonzo, Alessio Giaccone, Giorgio Baggi, Fulvio Moda, Fabio Brain Sci Review Parkinson’s disease (PD) is a neurodegenerative disorder often associated with pre-motor symptoms involving both gastrointestinal and olfactory tissues. PD patients frequently suffer from hyposmia, hyposalivation, dysphagia and gastrointestinal dysfunctions. During the last few years it has been speculated that microbial agents could play a crucial role in PD. In particular, alterations of the microbiota composition (dysbiosis) might contribute to the formation of misfolded α-synuclein, which is believed to be the leading cause of PD. However, while several findings confirmed that there might be an important link between intestinal microbiota alterations and PD onset, little is known about the potential contribution of the nasal microbiota. Here, we describe the latest findings on this topic by considering that more than 80% of patients with PD develop remarkable olfactory deficits in their prodromal disease stage. Therefore, the nasal microbiota might contribute to PD, eventually boosting the gut microbiota in promoting disease onset. Finally, we present the applications of the seed amplification assays to the study of the gut and olfactory mucosa of PD patients, and how they could be exploited to investigate whether pathogenic bacteria present in the gut and the nose might promote α-synuclein misfolding and aggregation. MDPI 2022-11-19 /pmc/articles/PMC9688507/ /pubmed/36421902 http://dx.doi.org/10.3390/brainsci12111579 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Consonni, Alessandra Miglietti, Martina De Luca, Chiara Maria Giulia Cazzaniga, Federico Angelo Ciullini, Arianna Dellarole, Ilaria Linda Bufano, Giuseppe Di Fonzo, Alessio Giaccone, Giorgio Baggi, Fulvio Moda, Fabio Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays |
title | Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays |
title_full | Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays |
title_fullStr | Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays |
title_full_unstemmed | Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays |
title_short | Approaching the Gut and Nasal Microbiota in Parkinson’s Disease in the Era of the Seed Amplification Assays |
title_sort | approaching the gut and nasal microbiota in parkinson’s disease in the era of the seed amplification assays |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688507/ https://www.ncbi.nlm.nih.gov/pubmed/36421902 http://dx.doi.org/10.3390/brainsci12111579 |
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