Cargando…

SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS

SIMPLE SUMMARY: Genome-wide association studies have identified a vast number of cancer risk-associated loci harboring numerous single nucleotide polymorphisms that regulate gene expression and affect individual genetic susceptibility to cancer through different routes. Recently, there has been some...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Wenmin, Zhang, Te, Song, Xuming, Dong, Gaochao, Xu, Lin, Jiang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688512/
https://www.ncbi.nlm.nih.gov/pubmed/36428729
http://dx.doi.org/10.3390/cancers14225636
_version_ 1784836287153307648
author Yang, Wenmin
Zhang, Te
Song, Xuming
Dong, Gaochao
Xu, Lin
Jiang, Feng
author_facet Yang, Wenmin
Zhang, Te
Song, Xuming
Dong, Gaochao
Xu, Lin
Jiang, Feng
author_sort Yang, Wenmin
collection PubMed
description SIMPLE SUMMARY: Genome-wide association studies have identified a vast number of cancer risk-associated loci harboring numerous single nucleotide polymorphisms that regulate gene expression and affect individual genetic susceptibility to cancer through different routes. Recently, there has been some progress made regarding the molecular and biological mechanisms underlying the ways that genetic variation affects gene regulation. This review summarizes the molecular and biological mechanisms of genetic variation that affect gene regulation by drawing from the findings provided by past studies. ABSTRACT: Cancer ranks as the second leading cause of death worldwide, and, being a genetic disease, it is highly heritable. Over the past few decades, genome-wide association studies (GWAS) have identified many risk-associated loci harboring hundreds of single nucleotide polymorphisms (SNPs). Some of these cancer-associated SNPs have been revealed as causal, and the functional characterization of the mechanisms underlying the cancer risk association has been illuminated in some instances. In this review, based on the different positions of SNPs and their modes of action, we discuss the mechanisms underlying how SNPs regulate the expression of target genes to consequently affect tumorigenesis and the development of cancer.
format Online
Article
Text
id pubmed-9688512
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-96885122022-11-25 SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS Yang, Wenmin Zhang, Te Song, Xuming Dong, Gaochao Xu, Lin Jiang, Feng Cancers (Basel) Review SIMPLE SUMMARY: Genome-wide association studies have identified a vast number of cancer risk-associated loci harboring numerous single nucleotide polymorphisms that regulate gene expression and affect individual genetic susceptibility to cancer through different routes. Recently, there has been some progress made regarding the molecular and biological mechanisms underlying the ways that genetic variation affects gene regulation. This review summarizes the molecular and biological mechanisms of genetic variation that affect gene regulation by drawing from the findings provided by past studies. ABSTRACT: Cancer ranks as the second leading cause of death worldwide, and, being a genetic disease, it is highly heritable. Over the past few decades, genome-wide association studies (GWAS) have identified many risk-associated loci harboring hundreds of single nucleotide polymorphisms (SNPs). Some of these cancer-associated SNPs have been revealed as causal, and the functional characterization of the mechanisms underlying the cancer risk association has been illuminated in some instances. In this review, based on the different positions of SNPs and their modes of action, we discuss the mechanisms underlying how SNPs regulate the expression of target genes to consequently affect tumorigenesis and the development of cancer. MDPI 2022-11-17 /pmc/articles/PMC9688512/ /pubmed/36428729 http://dx.doi.org/10.3390/cancers14225636 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Wenmin
Zhang, Te
Song, Xuming
Dong, Gaochao
Xu, Lin
Jiang, Feng
SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
title SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
title_full SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
title_fullStr SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
title_full_unstemmed SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
title_short SNP-Target Genes Interaction Perturbing the Cancer Risk in the Post-GWAS
title_sort snp-target genes interaction perturbing the cancer risk in the post-gwas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688512/
https://www.ncbi.nlm.nih.gov/pubmed/36428729
http://dx.doi.org/10.3390/cancers14225636
work_keys_str_mv AT yangwenmin snptargetgenesinteractionperturbingthecancerriskinthepostgwas
AT zhangte snptargetgenesinteractionperturbingthecancerriskinthepostgwas
AT songxuming snptargetgenesinteractionperturbingthecancerriskinthepostgwas
AT donggaochao snptargetgenesinteractionperturbingthecancerriskinthepostgwas
AT xulin snptargetgenesinteractionperturbingthecancerriskinthepostgwas
AT jiangfeng snptargetgenesinteractionperturbingthecancerriskinthepostgwas