Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics via Phenotypic Differentiation

SIMPLE SUMMARY: We present the first mathematical model to describe the multiphasic dynamical treatment response in CAR-T cell kinetics through the differentiation of functional (distributed and effector), memory, and exhausted phenotypes, integrated with the dynamics of cancer cells. The CAR-T cell...

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Detalles Bibliográficos
Autores principales: Paixão, Emanuelle A., Barros, Luciana R. C., Fassoni, Artur C., Almeida, Regina C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688514/
https://www.ncbi.nlm.nih.gov/pubmed/36428671
http://dx.doi.org/10.3390/cancers14225576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688514/
https://www.ncbi.nlm.nih.gov/pubmed/36428671
http://dx.doi.org/10.3390/cancers14225576

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