Cargando…
Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics via Phenotypic Differentiation
SIMPLE SUMMARY: We present the first mathematical model to describe the multiphasic dynamical treatment response in CAR-T cell kinetics through the differentiation of functional (distributed and effector), memory, and exhausted phenotypes, integrated with the dynamics of cancer cells. The CAR-T cell...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688514/ https://www.ncbi.nlm.nih.gov/pubmed/36428671 http://dx.doi.org/10.3390/cancers14225576 |