Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes

The underlying mechanisms for statin-induced myopathy (SIM) are still equivocal. In this study, we employ Drosophila melanogaster to dissect possible underlying mechanisms for SIM. We observe that chronic fluvastatin treatment causes reduced general locomotion activity and climbing ability. In addit...

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Detalles Bibliográficos
Autores principales: Al-Sabri, Mohamed H., Behare, Neha, Alsehli, Ahmed M., Berkins, Samuel, Arora, Aadeya, Antoniou, Eirini, Moysiadou, Eleni I., Anantha-Krishnan, Sowmya, Cosmen, Patricia D., Vikner, Johanna, Moulin, Thiago C., Ammar, Nourhene, Boukhatmi, Hadi, Clemensson, Laura E., Rask-Andersen, Mathias, Mwinyi, Jessica, Williams, Michael J., Fredriksson, Robert, Schiöth, Helgi B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688544/
https://www.ncbi.nlm.nih.gov/pubmed/36428957
http://dx.doi.org/10.3390/cells11223528

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