Intracellular Injection of Brain Extracts from Alzheimer’s Disease Patients Triggers Unregulated Ca(2+) Release from Intracellular Stores That Hinders Cellular Bioenergetics

Strong evidence indicates that amyloid beta (Aβ) inflicts its toxicity in Alzheimer’s disease (AD) by promoting uncontrolled elevation of cytosolic Ca(2+) in neurons. We have previously shown that synthetic Aβ42 oligomers stimulate abnormal intracellular Ca(2+) release from the endoplasmic reticulum...

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Detalles Bibliográficos
Autores principales: Pensalfini, Anna, Umar, Abdul Rahim, Glabe, Charles, Parker, Ian, Ullah, Ghanim, Demuro, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688564/
https://www.ncbi.nlm.nih.gov/pubmed/36429057
http://dx.doi.org/10.3390/cells11223630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688564/
https://www.ncbi.nlm.nih.gov/pubmed/36429057
http://dx.doi.org/10.3390/cells11223630

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