Regorafenib Induces Senescence and Epithelial-Mesenchymal Transition in Colorectal Cancer to Promote Drug Resistance

Potential intrinsic resistance mechanisms to regorafenib were explored after short exposure (3 days) on five CRC cell lines (HCT-116, SW1116, LS-1034, SW480, Caco-2). The observation of senescence-like features led to the investigation of a drug-initiated phenotype switch. Following long-term exposu...

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Detalles Bibliográficos
Autores principales: Kehagias, Pashalina, Kindt, Nadège, Krayem, Mohammad, Najem, Ahmad, Agostini, Giulia, Acedo Reina, Elena, Bregni, Giacomo, Sclafani, Francesco, Journe, Fabrice, Awada, Ahmad, Ghanem, Ghanem E., Hendlisz, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688587/
https://www.ncbi.nlm.nih.gov/pubmed/36429091
http://dx.doi.org/10.3390/cells11223663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688587/
https://www.ncbi.nlm.nih.gov/pubmed/36429091
http://dx.doi.org/10.3390/cells11223663

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