Trabectedin Is Active against Two Novel, Patient-Derived Solitary Fibrous Pleural Tumor Cell Lines and Synergizes with Ponatinib

SIMPLE SUMMARY: Solitary fibrous tumor of the pleura (SFT) is an orphan disease resistant to standard systemic therapy. We managed to establish two patient-derived cell models characterized as SFT by the NAB2-STAT6 gene fusion. Cell lines were tested for drug responsiveness in vitro. Trabectedin and...

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Detalles Bibliográficos
Autores principales: Ghanim, Bahil, Baier, Dina, Pirker, Christine, Müllauer, Leonhard, Sinn, Katharina, Lang, Gyoergy, Hoetzenecker, Konrad, Berger, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688590/
https://www.ncbi.nlm.nih.gov/pubmed/36428694
http://dx.doi.org/10.3390/cancers14225602

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