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SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk
The superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the SOD2 gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by PCR-RFLP in healthy...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688594/ https://www.ncbi.nlm.nih.gov/pubmed/36354667 http://dx.doi.org/10.3390/cimb44110355 |
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author | Gallegos-Arreola, Martha P. Ramírez-Patiño, Ramiro Sánchez-López, Josefina Y. Zúñiga-González, Guillermo M. Figuera, Luis E. Delgado-Saucedo, Jorge I. Gómez-Meda, Belinda C. Rosales-Reynoso, Mónica A. Puebla-Pérez, Ana M. Lemus-Varela, María L. Garibaldi-Ríos, Asbiel F. Marín-Domínguez, Nayely A. Pacheco-Verduzco, Diana P. Mohamed-Flores, Emaan A. |
author_facet | Gallegos-Arreola, Martha P. Ramírez-Patiño, Ramiro Sánchez-López, Josefina Y. Zúñiga-González, Guillermo M. Figuera, Luis E. Delgado-Saucedo, Jorge I. Gómez-Meda, Belinda C. Rosales-Reynoso, Mónica A. Puebla-Pérez, Ana M. Lemus-Varela, María L. Garibaldi-Ríos, Asbiel F. Marín-Domínguez, Nayely A. Pacheco-Verduzco, Diana P. Mohamed-Flores, Emaan A. |
author_sort | Gallegos-Arreola, Martha P. |
collection | PubMed |
description | The superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the SOD2 gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by PCR-RFLP in healthy subjects and in breast cancer (BC) patients. The rs4880 and rs5746136 variants were associated with BC susceptibility when BC patients and the control group were compared for the CT, TT, CTCC, and the T alleles (p < 0.05). The CT genotype of the rs4880 variant showed significant statistical differences in patients and controls aged ≤ 45 years old, and with hormonal consumption (p < 0.05). The rs4880 variant was associated with BC patients with CTTT genotype and obesity, the presence of DM2-SAH, and a non-chemotherapy response (p < 0.05). Additionally, the rs5746136 variant was associated with susceptibility to BC with Ki-67 (≥20%), luminal A type BC, and a chemotherapy partial response (p < 0.05) in BC patients who carry TT, TC, and CTTT genotypes, respectively. The haplotype T/T (OR 1.98; 95% CI 1.20–3.26, p = 0.005) was observed to be a risk factor for BC. The rs4880 and rs5746136 variants in the SOD2 gene were associated with BC susceptibility. |
format | Online Article Text |
id | pubmed-9688594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96885942022-11-25 SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk Gallegos-Arreola, Martha P. Ramírez-Patiño, Ramiro Sánchez-López, Josefina Y. Zúñiga-González, Guillermo M. Figuera, Luis E. Delgado-Saucedo, Jorge I. Gómez-Meda, Belinda C. Rosales-Reynoso, Mónica A. Puebla-Pérez, Ana M. Lemus-Varela, María L. Garibaldi-Ríos, Asbiel F. Marín-Domínguez, Nayely A. Pacheco-Verduzco, Diana P. Mohamed-Flores, Emaan A. Curr Issues Mol Biol Article The superoxide dismutase (SOD) is the principal antioxidant defense system in the body that is activated by a reactive oxygen species. Some variants of the SOD2 gene have been associated with cancer. The rs4880 variant was determined by PCR real-time and the rs5746136 variant by PCR-RFLP in healthy subjects and in breast cancer (BC) patients. The rs4880 and rs5746136 variants were associated with BC susceptibility when BC patients and the control group were compared for the CT, TT, CTCC, and the T alleles (p < 0.05). The CT genotype of the rs4880 variant showed significant statistical differences in patients and controls aged ≤ 45 years old, and with hormonal consumption (p < 0.05). The rs4880 variant was associated with BC patients with CTTT genotype and obesity, the presence of DM2-SAH, and a non-chemotherapy response (p < 0.05). Additionally, the rs5746136 variant was associated with susceptibility to BC with Ki-67 (≥20%), luminal A type BC, and a chemotherapy partial response (p < 0.05) in BC patients who carry TT, TC, and CTTT genotypes, respectively. The haplotype T/T (OR 1.98; 95% CI 1.20–3.26, p = 0.005) was observed to be a risk factor for BC. The rs4880 and rs5746136 variants in the SOD2 gene were associated with BC susceptibility. MDPI 2022-10-26 /pmc/articles/PMC9688594/ /pubmed/36354667 http://dx.doi.org/10.3390/cimb44110355 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gallegos-Arreola, Martha P. Ramírez-Patiño, Ramiro Sánchez-López, Josefina Y. Zúñiga-González, Guillermo M. Figuera, Luis E. Delgado-Saucedo, Jorge I. Gómez-Meda, Belinda C. Rosales-Reynoso, Mónica A. Puebla-Pérez, Ana M. Lemus-Varela, María L. Garibaldi-Ríos, Asbiel F. Marín-Domínguez, Nayely A. Pacheco-Verduzco, Diana P. Mohamed-Flores, Emaan A. SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
title | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
title_full | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
title_fullStr | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
title_full_unstemmed | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
title_short | SOD2 Gene Variants (rs4880 and rs5746136) and Their Association with Breast Cancer Risk |
title_sort | sod2 gene variants (rs4880 and rs5746136) and their association with breast cancer risk |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688594/ https://www.ncbi.nlm.nih.gov/pubmed/36354667 http://dx.doi.org/10.3390/cimb44110355 |
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