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Differentiation of Motor Speech Disorders through the Seven Deviance Scores from MonPaGe-2.0.s

For the clinical assessment of motor speech disorders (MSDs) in French, the MonPaGe-2.0.s protocol has been shown to be sensitive enough to diagnose mild MSD based on a combination of acoustic and perceptive scores. Here, we go a step further by investigating whether these scores—which capture devia...

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Autores principales: Fougeron, Cécile, Kodrasi, Ina, Laganaro, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688649/
https://www.ncbi.nlm.nih.gov/pubmed/36358397
http://dx.doi.org/10.3390/brainsci12111471
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author Fougeron, Cécile
Kodrasi, Ina
Laganaro, Marina
author_facet Fougeron, Cécile
Kodrasi, Ina
Laganaro, Marina
author_sort Fougeron, Cécile
collection PubMed
description For the clinical assessment of motor speech disorders (MSDs) in French, the MonPaGe-2.0.s protocol has been shown to be sensitive enough to diagnose mild MSD based on a combination of acoustic and perceptive scores. Here, we go a step further by investigating whether these scores—which capture deviance on intelligibility, articulation, voice, speech rate, maximum phonation time, prosody, diadochokinetic rate—contribute to the differential diagnosis of MSDs. To this aim, we trained decision trees for two-class automatic classification of different pairs of MSD subtypes based on seven deviance scores that are computed in MonPaGe-2.0.s against matched normative data. We included 60 speakers with mild to moderate MSD from six neuropathologies (amyotrophic lateral sclerosis, Wilson, Parkinson and Kennedy disease, spinocerebellar ataxia, post-stroke apraxia of speech). The two-class classifications relied mainly on deviance scores from four speech dimensions and predicted with over 85% accuracy the patient’s correct clinical category for ataxic, hypokinetic and flaccid dysarthria; classification of the other groups (apraxia of speech and mixed dysarthria) was slightly lower (79% to 82%). Although not perfect and only tested on small cohorts so far, the classification with deviance scores based on clinically informed features seems promising for MSD assessment and classification.
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spelling pubmed-96886492022-11-25 Differentiation of Motor Speech Disorders through the Seven Deviance Scores from MonPaGe-2.0.s Fougeron, Cécile Kodrasi, Ina Laganaro, Marina Brain Sci Article For the clinical assessment of motor speech disorders (MSDs) in French, the MonPaGe-2.0.s protocol has been shown to be sensitive enough to diagnose mild MSD based on a combination of acoustic and perceptive scores. Here, we go a step further by investigating whether these scores—which capture deviance on intelligibility, articulation, voice, speech rate, maximum phonation time, prosody, diadochokinetic rate—contribute to the differential diagnosis of MSDs. To this aim, we trained decision trees for two-class automatic classification of different pairs of MSD subtypes based on seven deviance scores that are computed in MonPaGe-2.0.s against matched normative data. We included 60 speakers with mild to moderate MSD from six neuropathologies (amyotrophic lateral sclerosis, Wilson, Parkinson and Kennedy disease, spinocerebellar ataxia, post-stroke apraxia of speech). The two-class classifications relied mainly on deviance scores from four speech dimensions and predicted with over 85% accuracy the patient’s correct clinical category for ataxic, hypokinetic and flaccid dysarthria; classification of the other groups (apraxia of speech and mixed dysarthria) was slightly lower (79% to 82%). Although not perfect and only tested on small cohorts so far, the classification with deviance scores based on clinically informed features seems promising for MSD assessment and classification. MDPI 2022-10-29 /pmc/articles/PMC9688649/ /pubmed/36358397 http://dx.doi.org/10.3390/brainsci12111471 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fougeron, Cécile
Kodrasi, Ina
Laganaro, Marina
Differentiation of Motor Speech Disorders through the Seven Deviance Scores from MonPaGe-2.0.s
title Differentiation of Motor Speech Disorders through the Seven Deviance Scores from MonPaGe-2.0.s
title_full Differentiation of Motor Speech Disorders through the Seven Deviance Scores from MonPaGe-2.0.s
title_fullStr Differentiation of Motor Speech Disorders through the Seven Deviance Scores from MonPaGe-2.0.s
title_full_unstemmed Differentiation of Motor Speech Disorders through the Seven Deviance Scores from MonPaGe-2.0.s
title_short Differentiation of Motor Speech Disorders through the Seven Deviance Scores from MonPaGe-2.0.s
title_sort differentiation of motor speech disorders through the seven deviance scores from monpage-2.0.s
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688649/
https://www.ncbi.nlm.nih.gov/pubmed/36358397
http://dx.doi.org/10.3390/brainsci12111471
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