Cargando…
Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application
This study proposed a filter-free wavelength sensor with a double-well structure for detecting fluorescence without an optical filter. The impurity concentration was optimized and simulated to form a double-well-structured sensor, of which the result was consistent with the fabricated sensor. Furthe...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688660/ https://www.ncbi.nlm.nih.gov/pubmed/36421151 http://dx.doi.org/10.3390/bios12111033 |
_version_ | 1784836325717835776 |
---|---|
author | Choi, Yong-Joon Nakano, Kakeru Ide, Tomoya Sakae, Tsugumi Ichikawa, Ryosuke Hizawa, Takeshi Akai, Daisuke Takahashi, Kazuhiro Noda, Toshihiko Sawada, Kazuaki |
author_facet | Choi, Yong-Joon Nakano, Kakeru Ide, Tomoya Sakae, Tsugumi Ichikawa, Ryosuke Hizawa, Takeshi Akai, Daisuke Takahashi, Kazuhiro Noda, Toshihiko Sawada, Kazuaki |
author_sort | Choi, Yong-Joon |
collection | PubMed |
description | This study proposed a filter-free wavelength sensor with a double-well structure for detecting fluorescence without an optical filter. The impurity concentration was optimized and simulated to form a double-well-structured sensor, of which the result was consistent with the fabricated sensor. Furthermore, we proposed a novel wavelength detection method using the current ratio based on the silicon absorption coefficient. The results showed that the proposed method successfully detected single wavelengths in the 460–800 nm range. Additionally, we confirmed that quantification was possible using the current ratio of the sensor for a relatively wide band wavelength, such as fluorescence. Finally, the fluorescence that was emitted from the reagents ALEXA488, 594, and 680 was successfully identified and quantified. The proposed sensor can detect wavelengths without optical filters, which can be used in various applications in the biofield, such as POCT as a miniaturized wavelength detection sensor. |
format | Online Article Text |
id | pubmed-9688660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-96886602022-11-25 Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application Choi, Yong-Joon Nakano, Kakeru Ide, Tomoya Sakae, Tsugumi Ichikawa, Ryosuke Hizawa, Takeshi Akai, Daisuke Takahashi, Kazuhiro Noda, Toshihiko Sawada, Kazuaki Biosensors (Basel) Article This study proposed a filter-free wavelength sensor with a double-well structure for detecting fluorescence without an optical filter. The impurity concentration was optimized and simulated to form a double-well-structured sensor, of which the result was consistent with the fabricated sensor. Furthermore, we proposed a novel wavelength detection method using the current ratio based on the silicon absorption coefficient. The results showed that the proposed method successfully detected single wavelengths in the 460–800 nm range. Additionally, we confirmed that quantification was possible using the current ratio of the sensor for a relatively wide band wavelength, such as fluorescence. Finally, the fluorescence that was emitted from the reagents ALEXA488, 594, and 680 was successfully identified and quantified. The proposed sensor can detect wavelengths without optical filters, which can be used in various applications in the biofield, such as POCT as a miniaturized wavelength detection sensor. MDPI 2022-11-17 /pmc/articles/PMC9688660/ /pubmed/36421151 http://dx.doi.org/10.3390/bios12111033 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Choi, Yong-Joon Nakano, Kakeru Ide, Tomoya Sakae, Tsugumi Ichikawa, Ryosuke Hizawa, Takeshi Akai, Daisuke Takahashi, Kazuhiro Noda, Toshihiko Sawada, Kazuaki Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application |
title | Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application |
title_full | Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application |
title_fullStr | Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application |
title_full_unstemmed | Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application |
title_short | Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application |
title_sort | demonstrating a filter-free wavelength sensor with double-well structure and its application |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688660/ https://www.ncbi.nlm.nih.gov/pubmed/36421151 http://dx.doi.org/10.3390/bios12111033 |
work_keys_str_mv | AT choiyongjoon demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT nakanokakeru demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT idetomoya demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT sakaetsugumi demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT ichikawaryosuke demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT hizawatakeshi demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT akaidaisuke demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT takahashikazuhiro demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT nodatoshihiko demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication AT sawadakazuaki demonstratingafilterfreewavelengthsensorwithdoublewellstructureanditsapplication |