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Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application

This study proposed a filter-free wavelength sensor with a double-well structure for detecting fluorescence without an optical filter. The impurity concentration was optimized and simulated to form a double-well-structured sensor, of which the result was consistent with the fabricated sensor. Furthe...

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Autores principales: Choi, Yong-Joon, Nakano, Kakeru, Ide, Tomoya, Sakae, Tsugumi, Ichikawa, Ryosuke, Hizawa, Takeshi, Akai, Daisuke, Takahashi, Kazuhiro, Noda, Toshihiko, Sawada, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688660/
https://www.ncbi.nlm.nih.gov/pubmed/36421151
http://dx.doi.org/10.3390/bios12111033
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author Choi, Yong-Joon
Nakano, Kakeru
Ide, Tomoya
Sakae, Tsugumi
Ichikawa, Ryosuke
Hizawa, Takeshi
Akai, Daisuke
Takahashi, Kazuhiro
Noda, Toshihiko
Sawada, Kazuaki
author_facet Choi, Yong-Joon
Nakano, Kakeru
Ide, Tomoya
Sakae, Tsugumi
Ichikawa, Ryosuke
Hizawa, Takeshi
Akai, Daisuke
Takahashi, Kazuhiro
Noda, Toshihiko
Sawada, Kazuaki
author_sort Choi, Yong-Joon
collection PubMed
description This study proposed a filter-free wavelength sensor with a double-well structure for detecting fluorescence without an optical filter. The impurity concentration was optimized and simulated to form a double-well-structured sensor, of which the result was consistent with the fabricated sensor. Furthermore, we proposed a novel wavelength detection method using the current ratio based on the silicon absorption coefficient. The results showed that the proposed method successfully detected single wavelengths in the 460–800 nm range. Additionally, we confirmed that quantification was possible using the current ratio of the sensor for a relatively wide band wavelength, such as fluorescence. Finally, the fluorescence that was emitted from the reagents ALEXA488, 594, and 680 was successfully identified and quantified. The proposed sensor can detect wavelengths without optical filters, which can be used in various applications in the biofield, such as POCT as a miniaturized wavelength detection sensor.
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spelling pubmed-96886602022-11-25 Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application Choi, Yong-Joon Nakano, Kakeru Ide, Tomoya Sakae, Tsugumi Ichikawa, Ryosuke Hizawa, Takeshi Akai, Daisuke Takahashi, Kazuhiro Noda, Toshihiko Sawada, Kazuaki Biosensors (Basel) Article This study proposed a filter-free wavelength sensor with a double-well structure for detecting fluorescence without an optical filter. The impurity concentration was optimized and simulated to form a double-well-structured sensor, of which the result was consistent with the fabricated sensor. Furthermore, we proposed a novel wavelength detection method using the current ratio based on the silicon absorption coefficient. The results showed that the proposed method successfully detected single wavelengths in the 460–800 nm range. Additionally, we confirmed that quantification was possible using the current ratio of the sensor for a relatively wide band wavelength, such as fluorescence. Finally, the fluorescence that was emitted from the reagents ALEXA488, 594, and 680 was successfully identified and quantified. The proposed sensor can detect wavelengths without optical filters, which can be used in various applications in the biofield, such as POCT as a miniaturized wavelength detection sensor. MDPI 2022-11-17 /pmc/articles/PMC9688660/ /pubmed/36421151 http://dx.doi.org/10.3390/bios12111033 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Yong-Joon
Nakano, Kakeru
Ide, Tomoya
Sakae, Tsugumi
Ichikawa, Ryosuke
Hizawa, Takeshi
Akai, Daisuke
Takahashi, Kazuhiro
Noda, Toshihiko
Sawada, Kazuaki
Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application
title Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application
title_full Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application
title_fullStr Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application
title_full_unstemmed Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application
title_short Demonstrating a Filter-Free Wavelength Sensor with Double-Well Structure and Its Application
title_sort demonstrating a filter-free wavelength sensor with double-well structure and its application
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688660/
https://www.ncbi.nlm.nih.gov/pubmed/36421151
http://dx.doi.org/10.3390/bios12111033
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