Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model

SIMPLE SUMMARY: Fumarate hydratase (FH) is an evolutionary conserved TCA cycle enzyme and has a moonlight function in the DNA damage response (DDR). FH has a contradictory function, as it is pro-survival through its role in the TCA cycle, yet its loss can drive tumorigenesis. Here, we solve this con...

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Detalles Bibliográficos
Autores principales: Solaimuthu, Balakrishnan, Lichtenstein, Michal, Hayashi, Arata, Khatib, Anees, Plaschkes, Inbar, Nevo, Yuval, Tanna, Mayur, Pines, Ophry, Shaul, Yoav D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688661/
https://www.ncbi.nlm.nih.gov/pubmed/36428601
http://dx.doi.org/10.3390/cancers14225508

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