Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation

Overexpression of α-synuclein with tyrosine mutated to phenylalanine at position 125 leads to a severe phenotype with motor impairment and neuropathology in Drosophila. Here, we hypothesized that tyrosine mutations would similarly lead to impaired motor performance with neuropathology in a rodent mo...

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Detalles Bibliográficos
Autores principales: Lassen, Louise Berkhoudt, Thomsen, Maj Schneider, Basso, Elisa, Füchtbauer, Ernst-Martin, Füchtbauer, Annette, Outeiro, Tiago Fleming, Jensen, Poul Henning, Moos, Torben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688722/
https://www.ncbi.nlm.nih.gov/pubmed/36429099
http://dx.doi.org/10.3390/cells11223673

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