The Role of WRAP53 in Cell Homeostasis and Carcinogenesis Onset

The WD repeat containing antisense to TP53 (WRAP53) gene codifies an antisense transcript for tumor protein p53 (TP53), stabilization (WRAP53α), and a functional protein (WRAP53β, WDR79, or TCAB1). The WRAP53β protein functions as a scaffolding protein that is important for telomerase localization,...

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Detalles Bibliográficos
Autores principales: Gadelha, Renan Brito, Machado, Caio Bezerra, Pessoa, Flávia Melo Cunha de Pinho, Pantoja, Laudreísa da Costa, Barreto, Igor Valentim, Ribeiro, Rodrigo Monteiro, de Moraes Filho, Manoel Odorico, de Moraes, Maria Elisabete Amaral, Khayat, André Salim, Moreira-Nunes, Caroline Aquino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688736/
https://www.ncbi.nlm.nih.gov/pubmed/36354684
http://dx.doi.org/10.3390/cimb44110372
Descripción
Sumario:The WD repeat containing antisense to TP53 (WRAP53) gene codifies an antisense transcript for tumor protein p53 (TP53), stabilization (WRAP53α), and a functional protein (WRAP53β, WDR79, or TCAB1). The WRAP53β protein functions as a scaffolding protein that is important for telomerase localization, telomere assembly, Cajal body integrity, and DNA double-strand break repair. WRAP53β is one of many proteins known for containing WD40 domains, which are responsible for mediating a variety of cell interactions. Currently, WRAP53 overexpression is considered a biomarker for a diverse subset of cancer types, and in this study, we describe what is known about WRAP53β’s multiple interactions in cell protein trafficking, Cajal body formation, and DNA double-strand break repair and its current perspectives as a biomarker for cancer.

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